Towards Development of a Nonhuman Primate Model of Carpal Tunnel Syndrome: Performance of a Voluntary, Repetitive Pinching Task Induces Median Mononeuropathy in Macaca fascicularis

Details

• Personal Author:
  Banks JJ ; Buford JA ; Korkmaz SV ; Lavender SA ; Pease WS ; Sommerich CM
• Description:
  This study investigated changes in median sensory nerve conduction velocity (SNCV) over several weeks of exposure to a voluntary, moderately forceful, repetitive pinching task performed for food rewards by a small sample of young adult female monkeys (Macaca fascicularis). SNCV, derived from peak latency, decreased significantly in the working hands of three of the four subjects. The overall decline in NCV was 25%-31% from baseline. There was no decrease in SNCV in the contralateral, nonworking hands. Several weeks after being removed from the task, SNCV returned to within 87%-100% of baseline. MRI showed enlargement of the affected nerves near the proximal end of the carpal tunnel, at the time of maximal SNCV slowing. This new animal model demonstrates a temporally unambiguous relationship between exposure to a moderately forceful, repetitive manual task and development of median mononeuropathy at the wrist, and recovery of SNCV following termination of task exposure. This study contributes to the pattern of evidence of a causal relationship between manual work, median mononeuropathy, and carpal tunnel syndrome in humans. In the future, this new animal model could be used to characterize dose-response relationships between risk factors and carpal tunnel syndrome. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Environmental Pollution Musculoskeletal Diseases Musculoskeletal System Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Animal-studies Biological-effects Carpal-tunnel-syndrome Environmental-contamination Environmental-exposure Manual-materials-handling Mathematical-models Mechanical-properties Models Musculoskeletal-system-disorders Physical-stress Qualitative-analysis Repetitive-work Risk-analysis Risk-factors

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• ISSN:
  0736-0266
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  25
• Issue:
  6
• NIOSHTIC Number:
  nn:20032204
• Citation:
  J Orthop Res 2007 Jun; 25(6):713-724
• Contact Point Address:
  Carolyn M. Sommerich, Department of Industrial, Welding and Systems Engineering, The Ohio State University, 1971 Neil Avenue, Room 210, Columbus, Ohio 43210
• Email:
  sommerich.1@osu.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20050401
• Source Full Name:
  Journal of Orthopaedic Research
• End Date:
  20080331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73b06822078888496070234e09b1e43334db27c407709913abb60d179b045840473704ab3c414c6d8343c71db39e8d4e78193ae0dc54731cfa6adab171d19fff
• Download URL:
  https://stacks.cdc.gov/view/cdc/186242/cdc_186242_DS1.pdf
• File Type:
  [PDF - 284.65 KB ]