Permeation of a Malathion Formulation Through Nitrile Gloves

Details

• Personal Author:
  Lin YW ; Que Hee SS
• Description:
  Factors determining the permeation of a malathion formulation (Prent) and a reconstituted mixture of 12 components (Recon), 11 being alkybenzenes, were investigated for a lined, unsupported nitrile glove in an American Society for Testing and Materials-type permeation cell with liquid collection and gas chromatography/mass spectrometry analysis. Only the factors for both Prent and Recon that did not differ significantly at p = 0.001 were then used in a virial-type linear regression multivariate model. The logarithm of the steady-state permeation rate Ps correlated best with the logarithm of the composition of the challenge solutions (weight percentage, %). The liquid molar volume (MV), the logarithm of the octanol-water partition coefficient (log Kow), dipole moment (DM), and the Snyder elution strength (E degrees) also correlated best in that descending order using the logarithm of the weight percentage as the first term in a linear two-term equation for Ps. After accounting for both % and MV as logarithms, log Kow, DM, and log E degrees still were correlated significantly to Ps in that descending order. The final equation of best fit involved an initial term for composition (log [%]), a second term related to liquid molecular size (log MV), and a hydrophobicity partitioning term (log Kow). Similar correlations were also found for log(Ps/t1) and log[VR(ts1)], where t1 was the lag time and ts1 was the first observed time in the steady state. This is the first successful model for glove permeation of complex mixtures of more than three components. [Description provided by NIOSH]
• Subjects:
  Chemistry Chemistry, Analytic Insecticides Nitriles Occupational Health Personal Protective Equipment Protective Clothing Safety Skin
• Keywords:
  Analytical-chemistry Chemical-analysis Exposure-limits Gloves Pesticides Protective-clothing Skin-tests
• ISSN:
  1047-322X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  286-298
• Volume:
  13
• Issue:
  5
• NIOSHTIC Number:
  nn:20031976
• Citation:
  Appl Occup Environ Hyg 1998 May; 13(5):286-298
• CAS Registry Number:
  Cumene (CAS RN 98-82-8) ; Malathion (CAS RN 121-75-5) ; m-Xylene (CAS RN 108-38-3) ; O,O-Diethyl phosphorochloridothioate (CAS RN 2524-04-1) ; o-Xylene (CAS RN 95-47-6)
• Federal Fiscal Year:
  1998
• Performing Organization:
  University of California, School of Public Health, Department of Environmental Health Sciences, Los Angeles, California
• Peer Reviewed:
  True
• Start Date:
  19920930
• Source Full Name:
  Applied Occupational and Environmental Hygiene
• End Date:
  19990331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3191d667ca61b464409e0bc4e3038ea1b4fb9e8ce1fae5410f95e449479ec62643e720c55eff88884e791096ac1c42a2986fe911c020b7e2cc0a9de19286e3e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/186082/cdc_186082_DS1.pdf
• File Type:
  [PDF - 1.21 MB ]