Carbon Nanotube Respiratory Exposure and Risk from Systemic Effects

Details

• Personal Author:
  Erdely A ; Li Z ; Simeonova PP
• Description:
  The most attractive features of nanomaterials including their small size, large surface area, and reactivity might also be the main factors for their toxicity. In this regard, nanoparticles may induce not only higher damage at the penetration site but also can lead to unexpected distant responses as a result of their transclocation and reactivity through the body. Our research efforts are currently directed to evaluate the cardiovascular effects, including vascular inflammation, blood cell coagulation status, atherosclerosis, as well as the related molecular mechanisms associated with respiratory exposure to different forms of carbon nanotubes (CNT) using animal models. We demonstrated that pulmonary exposure to multiple doses of single wall-CNT induces severe lung toxicity and accelerates the progression of atherosclerosis in ApoE-/- mice. This response is accompanied by oxidative modification in the vascular wall and induction of markers which facilitate blood coagulation. The atherogenic effects might be a result of a systemic effects related to the lung toxicity and/or translocation of nanotubes into the systemic circulation. The accumulation of toxicological data on engineered nanomaterials will allow for development of adequate risk assessment and regulations. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Irritants Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Biodynamics Blood-vessels Cardiovascular-function Cardiovascular-function-tests Cardiovascular-system-disorders Lung-disorders Nanotechnology Pulmonary-system-disorders Respiratory-infections Respiratory-irritants Respiratory-system-disorders

  More +
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  137
• Volume:
  96
• Issue:
  1
• NIOSHTIC Number:
  nn:20031914
• Citation:
  Toxicologist 2007 Mar; 96(1):137
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f906661870b4bb09f44c7cdbe98aa6e82269d322b9caa5615217d0d3af96e4250df74465474b2b51004109f75e841ab5f5a97441484da519d34e71730ed99447
• Download URL:
  https://stacks.cdc.gov/view/cdc/186025/cdc_186025_DS1.pdf
• File Type:
  [PDF - 517.26 KB ]