(2-Methoxyethoxy) Acetic Acid: A Urinary Biomarker of Exposure to JP-8 Jet Fuel

Details

• Personal Author:
  B'Hymer CB ; Butler MA ; Cheever KL ; Clark JC ; Gibson RL ; Krieg, Edward Jr. ; Toennis CA
• Description:
  (2-Methoxyethoxy)acetic acid (MEAA), the major urinary metabolite of the deicing agent 2-(2-methoxyethoxy)ethanol (diEGME) added to JP-8 jet fuel, was used to measure exposure to JP-8 in air force personnel at six airbases in the United States. JP-8 is a kerosene based fuel containing over 200 different compounds, including aliphatics, aromatics, benzene, and naphthalene, all of which vary in concentration depending upon the specific batch of JP-8. DiEGME is always present at 0.1 %. Post-shift urine specimens were obtained from personnel who performed fuel tank maintenance and their attendants (high category, n = 98), fuel handlers (moderate category, n = 38) and personnel with no direct JP-8 contact (low category, n = 61). Urine containing a deuterated (2-butoxy)acetic acid internal standard was extracted with ethyl acetate, followed by esterification to the ethyl ester. The ethyl ester was extracted with methylene chloride and concentrated. Quantitation was by a gas chromatograph equipped with a mass spectrometer. The mean urinary MEAA level was significantly greater in the high (6.9, SD = 15.5 µg/ml) category, as compared to the means of the moderate (0.4, SD = 0.9 µg/ml, p = 0.0024) and low (0.1, SD = 0.02 µg/ml, p= 0.0002) categories. The maximum concentrations of urinary MEAA were 110.0 µg/ml, 4.8 µg/ml, and 0.2 µg/ml and the percent of measurements below the limit of detection (0.1 ug/ml) were 6%, 67%, and 97% for the high, moderate, and low categories, respectively. This study demonstrated that urinary MEAA can be used a biomarker of exposure to JP-8. [Description provided by NIOSH]
• Subjects:
  Aircraft Biomarkers Epidemiology Fuel Oils Occupational Health Safety Urine
• Keywords:
  Cell-alteration Cell-biology Cell-damage Cell-function Cell-metabolism Cell-morphology Cell-transformation Cellular-reactions Fuels Gas-adsorption Jet-engine-fuels Urinalysis Urine-chemistry

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  85
• Volume:
  96
• Issue:
  1
• NIOSHTIC Number:
  nn:20031902
• Citation:
  Toxicologist 2007 Mar; 96(1):85
• CAS Registry Number:
  (2-Methoxyethoxy)acetic acid (CAS RN 16024-56-9) ; Diethylene glycol monomethyl ether (CAS RN 111-77-3)
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Healthcare and Social Assistance ; Manufacturing
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bcd4a09112ebb1b763dedb4c73ae311b65e917caef556126e0c0970e44280fae81c33ba4e06ca6ec57072bf9cab0fc009c3aa5272d66f6ed704a700a59609e82
• Download URL:
  https://stacks.cdc.gov/view/cdc/186014/cdc_186014_DS1.pdf
• File Type:
  [PDF - 518.55 KB ]