Comparison of Pulmonary Responses to Single-Walled vs. Multi-Walled Carbon Nanotubes

Details

• Personal Author:
  Castranova, Vincent
• Description:
  Exposure of mice to purified single-walled carbon nanotubes (<0.25% iron) by pharyngeal aspiration resulted in a rapid but transient inflammatory response as well as an early onset and progressive fibrotic reaction. Labeling of single-walled carbon nanotubes with gold nanoparticles indicated that granulomas occurred at deposition sites of large agglomerates, while interstitial fibrosis was associated with deposition of more dispersed nanotube structures. Techniques were developed to improve the dispersion of single-walled nanotubes. Aspiration of this dispersed single- walled carbon nanotube sample resulted in greater interstitial fibrosis in the absence of granulomas. Aspiration of a dispersed preparation of gold-labeled singlewalled carbon nanotubes resulted in rapid movement of nanotube structures into the alveolar interstitium and measurable translocation to systemic organs. Mice are currently being exposed by pharyngeal aspiration to a dispersed preparation of purified multi-walled carbon nanotubes. Results of these studies will be compared to those of single-walled carbon nanotubes to evaluate the effect of nanotube dimension (diameter) on pulmonary response. Single-walled carbon nanotubes were also evaluated in vitro to determine their ability to generate reactive species and stimulate oxidant production from macrophages. In vitro assays were not very good predictors of the in vivo fibrogenic potential of single-walled carbon nanotubes. In conclusion, results indicate that it would be prudent to implement strategies to limit exposure to carbon nanotubes in the workplace. [Description provided by NIOSH]
• Subjects:
  Aerosols Asthma Asthma, Occupational Dust Metals Occupational Health Particulate Matter Respiratory Tract Diseases Safety
• Keywords:
  Bronchial-asthma Metal-compounds Metal-dusts Metallic-compounds Metallic-dusts Nanotechnology Particulate-dust Pulmonary-system-disorders Respirable-dust Respiratory-system-disorders
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8
• Volume:
  96
• Issue:
  1
• NIOSHTIC Number:
  nn:20031894
• Citation:
  Toxicologist 2007 Mar; 96(1):8
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bab07e14b38d42b0339d8648b71fcfa4190f8e791a621af2e995c5a46f646f03cd8dbc614b5e95b5a1b46a3dd9504add1edad6376cd36febcfc6cedf99477ad8
• Download URL:
  https://stacks.cdc.gov/view/cdc/186006/cdc_186006_DS1.pdf
• File Type:
  [PDF - 518.82 KB ]