Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States

Goldstein, Edward; Kirkcaldy, Robert D.; Reshef, David; Berman, Stuart; Weinstock, Hillard; Sabeti, Pardis; Del Rio, Carlos; Hall, Geraldine; Hook, Edward W.; Lipsitch, Marc

doi:10.3201/eid1808.111202

i

Factors Related to Increasing Prevalence of Resistance to Ciprofloxacin and Other Antimicrobial Drugs in Neisseria gonorrhoeae, United States

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Aug 2012
By Goldstein, Edward ; Kirkcaldy, Robert D. ; Reshef, David ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Goldstein, Edward ; Kirkcaldy, Robert D. ; Reshef, David ; Berman, Stuart ; Weinstock, Hillard ; Sabeti, Pardis ; Del Rio, Carlos ; Hall, Geraldine ; Hook, Edward W. ; Lipsitch, Marc
Description:

Using data from the Gonococcal Isolate Surveillance Project, we studied changes in ciprofloxacin resistance in Neisseria gonorrhoeae isolates in the United States during 2002-2007. Compared with prevalence in heterosexual men, prevalence of ciprofloxacin-resistant N. gonorrhoeae infections showed a more pronounced increase in men who have sex with men (MSM), particularly through an increase in prevalence of strains also resistant to tetracycline and penicillin. Moreover, that multidrug resistance profile among MSM was negatively associated with recent travel. Across the surveillance project sites, first appearance of ciprofloxacin resistance in heterosexual men was positively correlated with such resistance for MSM. The increase in prevalence of ciprofloxacin resistance may have been facilitated by use of fluoroquinolones for treating gonorrhea and other conditions. The prominence of multidrug resistance suggests that using other classes of antimicrobial drugs for purposes other than treating gonorrhea helped increase the prevalence of ciprofloxacin-resistant strains that are also resistant to those drugs.
Subjects:

Anti-Infective Agents Ciprofloxacin CME Drug Resistance, Bacterial Female Gonorrhea Heterosexuality Homosexuality, Male Humans Male Microbial Sensitivity Tests Prevalence Risk Factors Sentinel Surveillance Travel
Source:

Emerg Infect Dis. 18(8):1290-1297.
Document Type:

Journal Article
Funding:

1 U54 GM088558/GM/NIGMS NIH HHS/United States ; 1H25PS001412/PS/NCHHSTP CDC HHS/United States ; K01 AI101010/AI/NIAID NIH HHS/United States ; U54 GM088558/GM/NIGMS NIH HHS/United States
Place as Subject:

United States
Location:

North America
Volume:

18
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:f4391db02b8a2e5f49f57a5c3dfe7644f1673752f69457eb53f052a778ad5f51
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https://stacks.cdc.gov/view/cdc/18599/cdc_18599_DS1.pdf
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[PDF - 310.93 KB ]

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