The 15-Country Collaborative Study of Cancer Risk Among Radiation Workers in the Nuclear Industry: Estimates of Radiation-Related Cancer Risks

Details

• Personal Author:
  Ahn YO ; Amoros E ; Ashmore P ; Auvinen A ; Bae JM ; Bermann F ; Bernar J ; Biau A ; Blettner M ; Cardis E ; Combalot E ; Cowper G ; Deboodt P ; Diez-Sacristan A ; Eklöf M ; Engels H ; Engholm G ; Fix J ; Gilbert E ; Gulis G ; Habib RR ; Hacker C ; Hakama M ; Heinmiller B ; Hill C ; Holan K ; Howe G ; Hyvonen H ; Kaldor J ; Kerekes A ; Kurtinaitis J ; Malker H ; Marshall M ; Martuzzi M ; Mastauskas A ; Monnet A ; Moser M ; Muirhead CR ; Pearce MS ; Richardson DB ; Rodriguez-Artalejo F ; Rogel A ; Schubauer-Berigan, Mary K. ; Tardy H ; Telle-Lamberton M ; Thierry-Chef I ; Turai I ; Usel M ; Utterback D ; Veress K ; Vrijheid M ; Yoshimura T
• Description:
  A 15-Country collaborative cohort study was conducted to provide direct estimates of cancer risk following protracted low doses of ionizing radiation. Analyses included 407,391 nuclear industry workers monitored individually for external radiation and 5.2 million person-years of follow-up. A significant association was seen between radiation dose and all-cause mortality [excess relative risk (ERR) 0.42 per Sv, 90% CI 0.07, 0.79; 18,993 deaths]. This was mainly attributable to a dose-related increase in all cancer mortality (ERR/Sv 0.97, 90% CI 0.28, 1.77; 5233 deaths). Among 31 specific types of malignancies studied, a significant association was found for lung cancer (ERR/Sv 1.86, 90% CI 0.49, 3.63; 1457 deaths) and a borderline significant (P = 0.06) association for multiple myeloma (ERR/Sv 6.15, 90% CI <0, 20.6; 83 deaths) and ill-defined and secondary cancers (ERR/Sv 1.96, 90% CI -0.26, 5.90; 328 deaths). Stratification on duration of employment had a large effect on the ERR/Sv, reflecting a strong healthy worker survivor effect in these cohorts. This is the largest analytical epidemiological study of the effects of low-dose protracted exposures to ionizing radiation to date. Further studies will be important to better assess the role of tobacco and other occupational exposures in our risk estimates. [Description provided by NIOSH]
• Subjects:
  Environmental Pollution Epidemiology Lung Lung Diseases Musculoskeletal System Neoplasms Occupational Exposure Occupational Health Radiation Respiratory System Respiratory Tract Diseases Safety Tobacco Products Workplace

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• Keywords:
  Bone-marrow Cancer-rates Environmental-contamination Lung-cancer Lung-cells Nuclear-hazards Nuclear-radiation Occupational-exposure Radiation-contamination Radiation-effects Radiation-exposure Radiation-measurement Radiation-properties Radiation-sources Radiation-tolerance Radioactive-measurement Spinal-cord-disorders Tobacco Work-environment Workplace-monitoring

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• ISSN:
  0033-7587
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; Ohio ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  396-416
• Volume:
  167
• Issue:
  4
• NIOSHTIC Number:
  nn:20031820
• Citation:
  Radiat Res 2007 Apr; 167(4):396-416
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Radiation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b04af94cf8209f8808de4f793824a0ed38252ac7f7e04c1938dd9d0a76aa857afbfc42c6ff11d5ea7f09838ad10d9493372a217579387d9e4a53f50c61b163a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/185967/cdc_185967_DS1.pdf
• File Type:
  [PDF - 303.69 KB ]