Risk of Chronic Myeloid and Acute Leukemia Mortality After Exposure to Ionizing Radiation Among Workers at Four U.S. Nuclear Weapons Facilities and a Nuclear Naval Shipyard

Details

• Personal Author:
  Ahrenholz, Steven H. ; Anderson, Jeri L. ; Burphy JS ; Couch, James R. ; Daniels, Robert D. ; Fleming DA ; Markey AM ; Schubauer-Berigan, Mary K. ; Tseng, Chih-Yu ; Ahrenholz, Steven H. ; Anderson, Jeri L. ; Burphy JS ; Couch, James R. ; Daniels, Robert D. ; Fleming DA ; Markey AM ; Schubauer-Berigan, Mary K. ; Tseng, Chih-Yu
• Description:
  A nested case-control study was conducted among workers at five U.S. nuclear facilities to evaluate leukemia mortality risk (excluding chronic lymphocytic) from ionizing radiation using worksite doses and adjusting for potential confounding. Conditional logistic regression was used to estimate the relative risk (RR) of exposed workers and the excess relative risk (ERR) per unit of radiation among 206 cases and 823 age-matched controls. Adjusting for sex and benzene, the RR of leukemia for workers receiving more than 10 mSv was higher compared to those receiving lower or no dose; however, the risk increase was attenuated in the highest dose group. The ERR per 10 mSv was 1.44% (95% CI: <-1.03%, 7.59%) but was higher for workers born after 1921 compared to workers born earlier or when excluding leukemias of uncertain type. Excluding the 7% who were high-dose workers (>100 mSv), the sex- and benzene-adjusted ERR per 10 mSv was 6.82% (95% CI: -2.87%, 24.1%). The results suggest that risks among these nuclear workers are comparable to those observed in high-dose populations, although no evidence was observed of a positive quadratic dose-response term in this study. This large study is among the first to jointly evaluate benzene and ionizing radiation risk. [Description provided by NIOSH]
• Subjects:
  Benzene Case Reports Hematologic Diseases Neoplasms Occupational Health Radiation Safety
• Keywords:
  Benzenes Blood-disorders Cancer Case-studies Ionizing-radiation Nuclear-radiation Radiation-exposure Statistical-analysis
• ISSN:
  0033-7587
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  222-232
• Volume:
  167
• Issue:
  2
• NIOSHTIC Number:
  nn:20031531
• Citation:
  Radiat Res 2007 Feb; 167(2):222-232
• Contact Point Address:
  NIOSH, DSHEFS, MS-R15, 4676 Columbia Parkway, Cincinnati, OH 45226
• CAS Registry Number:
  Benzene (CAS RN 71-43-2) ; Benzene (CAS RN 71-43-2)
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Radiation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:630b66241c215c0bf2f8ccd0bc7e64e527ba349a5df9c268fb57aaa9476c659b7eaea5baa95cd237b82979987eba440ad2ef5213e18c537f1fb2fa52374bfb42
• Download URL:
  https://stacks.cdc.gov/view/cdc/185789/cdc_185789_DS1.pdf
• File Type:
  [PDF - 116.96 KB ]