Immunotoxicology of Jet Propulsion Fuel-8

Details

• Personal Author:
  Keil DE
• Description:
  During the early 1990s, JP-8 emerged as the universal fuel for aircraft, land-based vehicles, and heaters/air conditioning generators used during military deployments. This was concurrent with increased occupational exposure reports describing adverse health effects associated with the use of JP-8. Coupled with the emergence of Gulf War Illness, increased emphasis has been placed on determining potential health effects of JP-8 exposure. Due to the fact that JP-8 contains hundreds of aliphatic and aromatic hydrocarbons, in addition to various performance additives, this complex mixture poses a serious challenge for risk assessment. Exposure assessment is complicated by the fact that JP-8 may be encountered as a vapor, aerosol, or liquid, and possibly as combustible products, and each physical state may contain different chemical entities. However, progress has been made in the identification of JP-8 components that may serve as reliable and predictable biomarkers of exposure, particularly for dermal exposures [12,35,81,82,83,84]. Studies have consistently identified the immune system as a target for JP-8. Due to variability in routes of exposure and chemical composition, it is likely that there are a number of pathways contributing to the development of immunotoxicity, including the generation of free radicals, release of platelet-activating factor, interference with immunological memory, or the alteration of neuropeptides and cytokines. With further examination of these various mechanisms combined with additional host resistance models, a greater understanding of risk to infectious disease or cancer will be improved. [Description provided by NIOSH]
• Subjects:
  Aircraft Fuel Oils Hydrocarbons Immune System Occupational Health Polycyclic Aromatic Hydrocarbons Risk Assessment Safety
• Keywords:
  Aliphatic-hydrocarbons Aromatic-hydrocarbons Fuels Immune-reaction Immune-system-disorders Immunologic-disorders Immunotoxins Jet-engine-fuels Military-personnel Risk-analysis
• ISBN:
  9780849337901
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  225-237
• NIOSHTIC Number:
  nn:20031431
• Citation:
  Immunotoxicology and immunopharmacology, 3rd edition. Luebke R, House R, Kimber I, eds. Boca Raton, FL: CRC Press, 2006 Dec; :225-237
• Editor(s):
  Luebke R; House R; Kimber I
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  False
• Source Full Name:
  Immunotoxicology and immunopharmacology, 3rd edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ebc3911fe9c024b8f680b8a5d2e3bded9a68a03c4798d2a8fda558d15a4e40c329bd873e41180bf54a7ca15f3a9ccf650eb8000a878e0b1b41ffe042934b4289
• Download URL:
  https://stacks.cdc.gov/view/cdc/185729/cdc_185729_DS1.pdf
• File Type:
  [PDF - 1.56 MB ]