Neurotoxic fragrance produces ceroid and myelin disease.

Details

• Personal Author:
  Foulds MM ; Horoupian DS ; Spencer PS ; Sterman AB
• Description:
  The neurotoxic changes occurring in rats exposed to the musk fragrance, acetyl-ethyl-tetramethyl-tetralin (88299) (AETT), were reviewed. The alterations included a ceroid like pigmentation, demyelination affecting the central and peripheral nervous systems, and behavioral changes associated with heightened irritability and limb weakness. A dose of 50mg/kg AETT per day induced a characteristic intermittent abnormal arching of the back concomitant with hopping ambulation, ataxia, and splaying. The behavioral changes were associated with a progressive blue discoloration of the skin, the eyes, the visceral organs, and nerve tracts. Structural changes affecting the nervous system included a progressive and irreversible lipopigmentation of neuronal perikarya, Schwann cells, astrocytes, and oligodendrocytes. Histochemical analysis of the neuronal lipopigment granules revealed similarities to the fluorescent and ultrastructural features of the ceroid lipopigment associated with human ceroid lipofuscinosis. Pigmentation was followed by demyelination characterized by splitting of the myelin sheath, edematous vacuolation, and myelin bubbling. The authors conclude that AETT may be useful for study of the etiology and pathogenesis of both neuronal lipopigment disorders and those myelinopathies associated with segmental bubbling of the myelin sheath. [Description provided by NIOSH]
• Subjects:
  Cosmetics Laboratories Microbiology Nervous System Occupational Health Safety
• Keywords:
  Cosmetics-industry Laboratory-animals Microscopic-analysis Nerve-tissue Neuropathology Neurotoxic-effects NIOSH-Grant NIOSH-Publication Peripheral-nervous-system
• ISSN:
  0036-8075
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  204
• Issue:
  4393
• NIOSHTIC Number:
  nn:00185562
• Citation:
  Science 1979 May; 204(4393):633-645
• Contact Point Address:
  Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
• CAS Registry Number:
  7-Acetyl-6-ethyl-1,1,4,4-tetramethyltetralin (CAS RN 88-29-9)
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Yeshiva University, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19751101
• Source Full Name:
  Science
• End Date:
  19850331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:391367dacc9f6712c3b58801a1d192f052d6c8a4a262aca2822becb10286002f8b1d68ca3edfbeeda27ea9ba372324e858b214d2d57b4556a38d287476afc46a
• Download URL:
  https://stacks.cdc.gov/view/cdc/185711/cdc_185711_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]