DNA hyperploidy as a marker for biological response to bladder carcinogen exposure.

Details

• Personal Author:
  Altekruse EB ; Hemstreet GP ; Ringen K ; Schulte, Paul A. ; Stringer, William T.
• Description:
  A study was undertaken to determine the extent to which DNA hyperploidy is a sensitive and specific marker for biological response to etiological factors for bladder cancer and whether the absolute nuclear fluorescence intensity (ANFI) methodology is a valid, relatively noninvasive means by which to identify DNA hyperploidy. Individuals in a 1385 member cohort were identified of their potentially high risk for bladder cancer due to their exposures to aromatic amines, primarily 2-naphthylamine (91598), and invited to participate in a screening program. Test results were provided for the 504 subjects who had ANFI urine cytology. When the population was classified by occupational exposure to aromatic amines, based on job category, the rates of positive ANFI results were 21.6 percent of the 74 exposed individuals and 3.5 percent of the 430 unexposed workers. For all ages the response was greater in the exposed group than in the unexposed group. The association between a positive response and age was significant for the unexposed group, but not for the exposed group. The rates of ANFI positive results were 7.7 percent in Blacks and 3.7 percent in Whites. None of the 26 women, all of whom were unexposed, was ANFI positive, compared with 31 of the 478 men. The prevalence of the marker was greatest for exposed workers who smoked, 23 percent, and lowest for those who had no exposure and who had not smoked, 2 percent. The authors conclude that DNA hyperploidy can serve as a marker for identifying workers who are at increased risk in occupational groups exposed to bladder carcinogens. [Description provided by NIOSH]
• Subjects:
  Carcinogens Neoplasms Occupational Health Polycyclic Aromatic Hydrocarbons Risk Assessment Risk Factors Safety Smokers Tobacco Products Urogenital Diseases Urogenital System

  More +
• Keywords:
  Aromatic-hydrocarbons Bladder-cancer Cancer-rates Cigarette-smoking Medical-screening NIOSH-Author Nucleic-acids Risk-factors Screening-methods
• ISSN:
  0020-7136
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Massachusetts ; Ohio ; Oklahoma ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  42
• Issue:
  6
• NIOSHTIC Number:
  nn:00185187
• Citation:
  Int J Cancer 1988 Dec; 42(6):817-820
• Contact Point Address:
  George P. Hemstreet, University of Oklahoma, Health Sciences Center, Urology Department, P.O. Box 26901, Oklahoma City, OK 73190, USA
• CAS Registry Number:
  2-Naphthylamine (CAS RN 91-59-8)
• Federal Fiscal Year:
  1989
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Cancer
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4659f27435d5215dff7bb81b9b30946407627797275e9a65eeb6502c54c4286d40260b8c0d018e2735179e7f931cb6b024ef1d818a4a523e125bb3e7f0134fa7
• Download URL:
  https://stacks.cdc.gov/view/cdc/185697/cdc_185697_DS1.pdf
• File Type:
  [PDF - 504.30 KB ]