Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction.

Details

• Personal Author:
  Cullen MR ; Schrader, Steven M. ; Turner TW ; Welch LS ; Cullen MR ; Schrader, Steven M. ; Turner TW ; Welch LS
• Description:
  Efforts were made to determine whether exposures to 2-ethoxyethanol (110805) (2-EE) or 2-methoxyethanol (109864) (2-ME) while employed as a painter at a shipyard had any effect on male reproduction. Semen samples were collected from 73 painters and 40 comparisons. These samples were analyzed for pH, volume, turbidity, liquidity, viability by stain exclusion and hypoosmotic stress, sperm density and count per ejaculate, motility, morphology and morphometry. Serum samples were analyzed for testosterone, follicular stimulating hormone and luteinizing hormone. Analysis of the work environment indicated the men were exposed to 2-EE at a time weighted average (TWA) concentration of 0 to 80.5mg/m3 with a mean of 9.9mg/m3 and to 2-ME at a TWA of 0 to 17.7mg/m3 with a mean of 2.6mg/m3. Increased prevalence of oligospermia and azoospermia was noted among the painters as well as an increased odds ratio for a lower sperm count per ejaculate. The finding that ethylene-glycol ethers affect reproductive function was consistent with results of earlier experiments and epidemiologic studies. [Description provided by NIOSH]
• Subjects:
  Ethanol Inhalation Exposure Occupational Health Safety Ships Solvents Urogenital Diseases Urogenital System
• Keywords:
  2-ethoxyethanol 2-methoxyethanol Author Keywords: Infertility Azoospermia Ethanols Fertility Inhalants NIOSH-Author Occupational Disease Oligospermia Organic-solvents Reproductive-effects Reproductive-system-disorders Shipbuilding-industry Shipyard-workers Solvent-vapors

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Connecticut ; District of Columbia ; Ohio ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences ; DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  14
• Issue:
  5
• NIOSHTIC Number:
  nn:00183119
• Citation:
  Am J Ind Med 1988 Nov; 14(5):509-526
• Contact Point Address:
  Dr. Laura S. Welch, Department of Medicine, George Washington University School of Medicine, 2150 Pennsylvania Ave., N.W., Washington, DC 20037
• CAS Registry Number:
  2-Methoxyethanol (CAS RN 109-86-4) ; Glycol monoethyl ether (CAS RN 110-80-5) ; 2-Methoxyethanol (CAS RN 109-86-4) ; Glycol monoethyl ether (CAS RN 110-80-5)
• Federal Fiscal Year:
  1989
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e4fee6323006bb28efcfcb52f9e3394a2d29f5ea948321b014e9048b26a989523595c9c457620d597e49049cbbb717cc7833802bb67794f47b79a5160064a403
• Download URL:
  https://stacks.cdc.gov/view/cdc/185654/cdc_185654_DS1.pdf
• File Type:
  [PDF - 1.06 MB ]