Development of a model for use in estimating exposure to ethylene oxide in a retrospective cohort mortality study.

Details

• Personal Author:
  Greife AL ; Hornung, Richard W. ; Stayner, Leslie T. ; Steenland KN
• Description:
  A model for estimating exposure to ethylene-oxide (75218) in a retrospective cohort mortality study was developed. The model based on a linear regression procedure was intended to estimate ethylene- oxide exposures by facility and year for a NIOSH cohort mortality study of workers in the medical supplies and spice industries. Ethylene-oxide exposure data were collected during walkthrough surveys of 36 companies and in/depth surveys of two companies. A total of 230 data points were used to develop the model. Twenty three independent variables were examined for their potential association with the logarithm of the average exposure expressed as parts per million (ppm) ethylene-oxide. Seven variables, year, volume of sterilizer or treatment vessel in cubic feet, product age, exposure category, product type, facilitated product aeration, and rear exhaust valve in the sterilizer or treatment vessel, and two interactive terms, exposure category times product type and exposure category category times year, explained 90 percent of the variance in the data. When used to estimate exposure concentrations for 46 other data points not used in developing the model, the average bias was -0.5ppm and the standard deviation was 5.6ppm. An evaluation of the same test data by a panel of experienced industrial hygienists yielded a bias of -2.9ppm and a standard deviation of 5.2ppm. The authors conclude that the model explains 90 percent of the variance in the ethylene-oxide data while using only a relatively few terms. [Description provided by NIOSH]
• Subjects:
  Epidemiology Epoxy Compounds Occupational Exposure Occupational Health Safety
• Keywords:
  Epoxides Industrial-hygiene Mathematical-models NIOSH-Author Occupational-exposure
• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  29-30
• Volume:
  14
• NIOSHTIC Number:
  nn:00181586
• Citation:
  Scand J Work Environ Health 1988 May/Jun; 14(Suppl 1):29-30
• Contact Point Address:
  National Institute for Occupational Safety and Health Cincinnati, Ohio, USA
• CAS Registry Number:
  Ethylene oxide (CAS RN 75-21-8)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b03545602ae2723be08a85bc3d662d6b62827fe9b70f1fb3ef791609366d82ae765f9e86cf88c8fe5ebab39e34760046a65c29f32ab281387551b23fe35f0546
• Download URL:
  https://stacks.cdc.gov/view/cdc/185602/cdc_185602_DS1.pdf
• File Type:
  [PDF - 1.37 MB ]