Teratogenicity of n-propanol and isopropanol administered at high inhalation concentrations to rats.

Details

• Personal Author:
  Brightwell WS ; Burg, Jeanne R. ; Khan A ; MacKenzie Taylor DR ; Nelson BK ; Weigel WW
• Description:
  The teratological effects of the inhalation of n-propanol (71238) and isopropanol (67630) were evaluated in rats. Pregnant female Sprague-Dawley-rats were exposed to the vapors of either isopropanol or n-propanol at concentrations of 3500, 7000, or 10,000 parts per million (ppm) in inhalation chambers for 7 hours per day on gestation days one through 19. The animals were sacrificed on gestation day 20, and the uterus, ovaries, corpora lutea, resorptions, and live fetuses were assessed. Exposure concentrations of 3500ppm and 7000ppm n-propanol and isopropanol had no significant effects on the female rats. Animals exposed to 10,000ppm isopropanol were narcotized at the end of their daily exposure whereas the same exposure concentration of n-propanol had minimal effects on the dams. The exposure of young female animals to 10,000ppm isopropanol for 7 hours resulted in narcotization followed by recovery whereas the same concentration of n-propanol resulted in narcotization followed by death. Reduced feed intake and weight gains were observed in dams exposed to 7000ppm and 10,000ppm isopropanol. Severe embryotoxicity was observed after gestational treatment with 10,000ppm n-propanol or isopropanol. Dose dependent reductions of fetal weight were observed after treatment with 7000 and 10,000ppm n-propanol and after treatment with all concentrations of isopropanol. Treatment with 10,000ppm n-propanol was associated with increased incidence of missing or short tails, ectrodactyly, rudimentary cervical ribs, and cardiovascular and urinary defects. Treatment with 7000 and 10,000ppm isopropanol was associated with rudimentary cervical ribs only. The authors conclude from the lack of effects at 3500ppm that n-propanol and isopropanol do not pose selective hazards to fetal development. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Hazardous Substances Laboratories Occupational Health Safety Solvents Teratogenesis Urogenital System
• Keywords:
  Alcohols Laboratory-animals NIOSH-Author Organic-solvents Organic-vapors Reproductive-effects Teratogens Teratology Toxic-effects
• ISSN:
  0278-6915
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Ohio ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  247-254
• Volume:
  26
• Issue:
  3
• NIOSHTIC Number:
  nn:00180601
• Citation:
  Food Chem Toxicol 1988 Mar; 26(3):247-254
• Contact Point Address:
  B. K. Nelson, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, C-24, Cincinnati, OH 45226
• CAS Registry Number:
  1-Propanol (CAS RN 71-23-8) ; Isopropanol (CAS RN 67-63-0)
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Food and Chemical Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:41797d38aaa20e0321b57d4866b3d45bbf9d2bd5c04a7b0af3bd5cd642a67f8a9edf9769a8e9153848ea73eaa9a18bbd710f4dddd2697f53f262d1a9f8a32199
• Download URL:
  https://stacks.cdc.gov/view/cdc/185555/cdc_185555_DS1.pdf
• File Type:
  [PDF - 648.73 KB ]