Interferon induction inhibition and mutagenic activity of nitrosated coal dust extract.

Details

• Personal Author:
  Booth JA ; Hahon N ; Stewart JD
• Description:
  The effect of nitrosated coal dust extract with and without microsomal enzymatic activation on viral interferon induction in mammalian cell cultures was studied. Rat liver S9 fraction was used for activation. Exposure to 1 to 5 milligrams of coal dust inhibited the interferon induction by influenza virus in LLC-MK2- rhesus-monkey kidney cell monolayers by more than 60 percent. A marked and comparable reduction of interferon induction was obtained by coal dust that was either nitrosated and acidified, acidified only, or untreated. The nitrosated coal dust extract was further extracted with horse serum. The soluble chemical complexes formed with fractions of high molecular weight without bioactivation were dominant in both mutagenicity and inhibition of interferon induction. Low molecular weight fractions all inhibited interferon induction comparably and significantly with or without bioactivation, with or without a metal chelator. No mutagenic activity was manifested by these serum fractions. The authors indicate that whether impairment of interferon production by a xenobiotic agent such as nitrosated coal dust is important in gastric carcinogenesis requires further study. [Description provided by NIOSH]
• Subjects:
  Carcinogens Coal Coal Mining Digestive System Digestive System Diseases Dust Laboratories Mining Occupational Health Safety
• Keywords:
  Carcinogenesis Coal-dust Coal-miners Gastrointestinal-system-disorders In-vitro-studies Laboratory-animals NIOSH-Author
• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  213-223
• Volume:
  45
• Issue:
  2
• NIOSHTIC Number:
  nn:00179953
• Citation:
  Environ Res 1988 Apr; 45(2):213-223
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5e758549c9dfec8b2b399cd590b048a9ef491b847c66cefcc73abc3ad29cbbbba5c24bf7cf698ba028ccc4e96adf2db05472563efcab75d86ab9afe9ae8e0a45
• Download URL:
  https://stacks.cdc.gov/view/cdc/185532/cdc_185532_DS1.pdf
• File Type:
  [PDF - 702.59 KB ]