Respiratory tract deposition of polydisperse aerosols in humans.

Details

• Personal Author:
  Diu CK ; Yu CP
• Description:
  The deposition of polydisperse aerosols of uniform composition using a computational model was investigated. For the purposes of this study the size distribution function adopted for the polydisperse aerosol was the lognormal distribution. This assumption was appropriate for single component aerosols. Total mass deposition fraction via nose and mouth breathing was calculated for a breathing condition of 1000 cubic centimeters tidal volume with 15 respirations per minute. Total deposition in the respiratory system approaches 100 percent for a monodisperse aerosol when particle diameter is greater than 10 micrometers or smaller than 0.005 micrometers. Deposition of polydisperse aerosols was expected to be lower than that of the monodisperse aerosol because the mass median diameter of the polydisperse aerosol was close to these values. The effect of particle size was further complicated by the sequential filtering effect of the various compartments in the respiratory system. The mobility of large particles was another problem in dealing with the deposition of polydisperse aerosols as this mobility is governed by the aerodynamic diameter while the geometric diameter is responsible for diffusion. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Inhalation Exposure Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Aerosol-sampling Airborne-particles Analytical-methods Inhalants Lung-burden NIOSH-Grant NIOSH-Publication Pulmonary-system-disorders
• ISSN:
  0002-8894
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  62-65
• Volume:
  44
• Issue:
  1
• NIOSHTIC Number:
  nn:00179524
• Citation:
  Am Ind Hyg Assoc J 1983 Jan; 44(1):62-65
• Federal Fiscal Year:
  1983
• Performing Organization:
  State University of New York at Buffalo, Buffalo, New York
• Peer Reviewed:
  True
• Start Date:
  19791201
• Source Full Name:
  American Industrial Hygiene Association Journal
• End Date:
  19861130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c2d63960c3cab7881d9e6fcb352b488ab071821b84d824c206a7d69ea3548c4b4c4fc00866b5e008aac3ae353e34d84c51a5c6203c237798e9e3ba844cf6a22d
• Download URL:
  https://stacks.cdc.gov/view/cdc/185513/cdc_185513_DS1.pdf
• File Type:
  [PDF - 521.57 KB ]