A study of some biological surfactants.

Details

• Personal Author:
  Mendenhall AL Jr. ; Mendenhall RM ; Tucker JH
• Description:
  Using a vertical pull surface balance, comparisons were developed between static and dynamic surface tensions of lung alveolar surfactant (LAS) and other biological surfactants. Two methods of measurement were used. The first permitted each surfactant the freedom to spread beyond the confines of the barriers of the surface balance at low surface tension. In the second method such spreading was inhibited. The findings from these studies were used to further understand the role of LAS in lung mechanics and to help reconcile the difference in static surface tensions of LAS which are obtained with the surface balance and those which are reported for bubbles derived from the same material. Surface films of LAS demonstrated a marked spreading tendency and local surface turbulence. This could provide a mechanism for transport at surfaces of this type of mucus. Films of LAS may be capable of converting chemical to mechanical energy. The authors suggest that the same surface properties demonstrated for LAS should exist to a variable degree at biological interfaces in general, including other mucous surfaces. Lung stability based on surface properties of bubbles lined with LAS, lung stability based on early surface balance studies, lung alveolar surface area and breathing movements, the spread of films of LAS from lung alveoli, and factors which inhibit the spread of LAS were discussed. [Description provided by NIOSH]
• Subjects:
  Lung Occupational Health Respiratory System Safety
• Keywords:
  Alveolar-cells Lung-cells Lung-function Mucous-membranes NIOSH-Author Pulmonary-function Pulmonary-system Surface-properties
• ISSN:
  0077-8923
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  130
• Issue:
  3
• NIOSHTIC Number:
  nn:00175525
• Citation:
  Ann NY Acad Sci 1966 Sep; 130(3):902-919
• Federal Fiscal Year:
  1966
• Peer Reviewed:
  True
• Source Full Name:
  Annals of the New York Academy of Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5b4fdd30444de257b63470e284ed0ce19be015607f79a7f523b99908467ac194fbdf3229bcfaf440cf634be3a0baa1745411af8263c32f5d524357ac60d59c23
• Download URL:
  https://stacks.cdc.gov/view/cdc/185381/cdc_185381_DS1.pdf
• File Type:
  [PDF - 4.55 MB ]