Airway epithelium modulates the reactivity of guinea-pig respiratory smooth muscle.

Details

• Personal Author:
  Farmer SG ; Fedan, Jeffery S. ; Fleming WW ; Hay DW ; Raeburn D ; Robinson VA
• Description:
  The reactivity of guinea-pig isolated trachea was studied with and without removal of airway epithelium. Dose response contractile curves were obtained for potassium-chloride (KCl), histamine, and methacholine in the presence and absence of indomethacin. Epithelium removal had no significant effect on the mechanical properties of isolated tracheal strips but increased the sensitivity of the tissue to both histamine and methacholine. The maximum contractile response of the tissue after epithelium removal was increased for histamine but was unchanged for methacholine. Epithelium removal yielded variable results for maximum contractile response to KCl treatment. Indomethacin incubation induced tissue relaxation in intact and epithelium denuded tracheal strips. Indomethacin treatment enhanced the maximal contractile response to KCl in the absence of epithelium and increased tissue sensitivity to methacholine in intact preparations. Indomethacin had no effect on tissue responses to histamine. The authors conclude that inhibitory and excitatory factors from epithelial cells regulate the reactivity of guinea-pig isolated airway smooth muscle. [Description provided by NIOSH]
• Subjects:
  Laboratories Lung Nervous System Occupational Health Respiratory System Safety
• Keywords:
  Dose-response In-vitro-studies Laboratory-animals Lung-tissue Muscle-cells Neuromuscular-function NIOSH-Author Physiological-response Pulmonary-function
• ISSN:
  0014-2999
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  11-18
• Volume:
  129
• Issue:
  1
• NIOSHTIC Number:
  nn:00174931
• Citation:
  Eur J Pharmacol 1986 Sep; 129(1-2):11-18
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• Source Full Name:
  European Journal of Pharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ed2f5b6c7c56cb96073e29e7c12793dcc36a3fd1dcfba032023d9521c30a766cdac2fed4cedd8e91b1f528abe461e7608303a709996f0219b28b9bbe02da8666
• Download URL:
  https://stacks.cdc.gov/view/cdc/185352/cdc_185352_DS1.pdf
• File Type:
  [PDF - 606.56 KB ]