Regional differences in gas trapping (airway closure) between apex and base of excised rat lungs.

Details

• Personal Author:
  Franz GN ; Frazer DG ; Morgan JJ
• Description:
  Regional differences in gas trapping between the apex and base of the lung were assessed in excised lungs from male Long-Evans-hooded- rats. The lungs were ventilated with air as they were suspended upright, inverted in saline, or supported upright in saline, and pressure volume curves were recorded for each of the three conditions. The distribution of transpulmonary pressures over which gas trapping occurred was evaluated by statistical analysis. Increasing uniformity of gas trapping was associated with a decreasing standard deviation for the distribution of transpulmonary pressures. The standard deviations for the distribution of transpulmonary pressures under the three conditions of the study were 1.10, 0.63, and 1.57 for the lung in air, inverted in saline, and upright in saline, respectively. The authors conclude that gas trapping in lungs occurs at the base before it occurs at the apex and that gas trapping for lungs inverted in saline is more uniformly distributed from apex to base than gas trapping in lungs either upright in saline or in air. [Description provided by NIOSH]
• Subjects:
  Air Movements Air Pressure Laboratories Lung Musculoskeletal System Occupational Health Respiratory System Safety
• Keywords:
  Air-flow Air-pressure Airway-obstruction Author Keywords: Airway Closure Gas Distribution In-vitro-studies Laboratory-animals Lung-function NIOSH-Author Physiology Posture Pulmonary-function Rat Trapped Gas

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• ISSN:
  0034-5687
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  309-316
• Volume:
  55
• Issue:
  3
• NIOSHTIC Number:
  nn:00174927
• Citation:
  Respir Physiol 1984 Mar; 55(3):309-316
• Federal Fiscal Year:
  1984
• Peer Reviewed:
  True
• Source Full Name:
  Respiratory Physiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7526b8c51d04ad1beb39099a92899f0e8d7d6b8048d67fe51cdb4d15493dcfea88672368da053533239e57e21eff88aad39d7ec51e4f75512e2cbd7f5688e921
• Download URL:
  https://stacks.cdc.gov/view/cdc/185348/cdc_185348_DS1.pdf
• File Type:
  [PDF - 510.21 KB ]