IgA glomerulonephritis in a plumber working with solvent-based pipe cement.

Details

• Personal Author:
  Albrecht, William N. ; Boiano, James M. ; Smith RD
• Description:
  A case was described of a 28 year old plumber who suffered from gross hematuria and segmental proliferative glomerulonephritis with immunoglobulin-A deposits who requested a health hazard evaluation from NIOSH. A detailed examination of needle biopsy material revealed the presence of capillary adhesions to Bowman's capsule and fibrin in the glomerular mesangial deposits, which was suggestive of a progressive autoimmune disease. He had been working with plastic pipe and plastic cement for 9.5 years and had no family history of kidney disease. Monitoring of his workplace identified a very high exposure (range, 389 to 757 parts per million (ppm)) to tetrahydrofuran (109999) (THF), which is a component of polyvinyl- chloride pipe cement. The high exposure values occurred while the plumber glued pipe sections in confined spaces. He was also potentially exposed to cyclohexanone (108941) and methylethyl-ketone (78933) which were also present in the cement. The concentration of cyclohexanone was not measurable, but that of methylethyl-ketone was in the range of 3.9 to 5.0ppm. The short term exposure limit for THF recommended by NIOSH is 250ppm. Although the authors do not conclude that the immunoglobulin-A nephropathy has been caused by THF, they suggest that a predisposition toward the disease could be exacerbated by the massive short term exposure to solvent. [Description provided by NIOSH]
• Subjects:
  Case Reports Furans Kidney Diseases Occupational Exposure Occupational Health Safety Solvents Urogenital Diseases Urogenital System Vinyl Chloride
• Keywords:
  Author Keywords: IgA Glomerulonephritis Case-studies Kidney-lesions Nephrological-disorders NIOSH-Author Occupational-exposure Occupational Kidney Disease Organic-solvents Plumbers Plumbing Hazards Tetrahydrofuran THF Vinyl-plastics

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• ISSN:
  0019-8366
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  157-158
• Volume:
  25
• Issue:
  3
• NIOSHTIC Number:
  nn:00174709
• Citation:
  Ind Health 1987 Jul; 25(3):157-158
• Contact Point Address:
  William N. Albrecht, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, Cincinnati, Ohio 45226, U.S.A.
• CAS Registry Number:
  Cyclohexanone (CAS RN 108-94-1) ; Methyl ethyl ketone (CAS RN 78-93-3) ; Tetrahydrofuran (CAS RN 109-99-9)
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  False
• Source Full Name:
  Industrial Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d8d004a826ae953ed8b29b1644e74f9fe252f54910f07be7b33601f870db39168dc586a6568a5357ccea58841e01ab0a89224cc4c970aff47ab83683a0380432
• Download URL:
  https://stacks.cdc.gov/view/cdc/185323/cdc_185323_DS1.pdf
• File Type:
  [PDF - 135.90 KB ]