Quantitative risk assessment of lung cancer in U.S. uranium miners.

Details

• Personal Author:
  Hornung, Richard W. ; Meinhardt, Theodore J.
• Description:
  Results of a study of quantitative risk estimates of lung cancer incidence subsequent to exposure to radon daughters in 3366 caucasian uranium miners were reported. A previously developed power function risk model provided the best fit to data as measured by the log likelihood. Studies on exposure rates suggested that among groups of underground miners receiving equivalent cumulative exposures, those exposed to lower levels for longer periods of time were at increased risk compared with those exposed to higher doses for shorter periods of time. It was determined that a miner who received a total exposure below 834 units of cumulative exposure at a rate 0.1 times as great as another miner of the same age, smoking status and cumulative exposure, would have a 58 percent greater risk of lung cancer. For miners in the 834 to 10000 units of cumulative exposure range, the increased risk would only be 10 percent at the lower exposure rate. Age was shown to influence cancer risk. For example, a miner who was initially exposed 10 years later in life than another miner with the same radon daughter exposure and smoking history, was shown to have a 32 percent higher risk of lung cancer. Relative risk of lung cancer fell sharply in the years following cessation of exposure. [Description provided by NIOSH]
• Subjects:
  Epidemiology Hazardous Substances Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Radiation Radiation Injuries Radon Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Uranium

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• Keywords:
  NIOSH-Author Occupational-exposure Pulmonary-cancer Radiation-exposure Radiation-injury Radon-daughters Risk-analysis Risk-factors Toxic-effects Uranium-miners
• ISSN:
  0017-9078
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  417-430
• Volume:
  52
• Issue:
  4
• NIOSHTIC Number:
  nn:00171058
• Citation:
  Health Phys 1987 Apr; 52(4):417-430
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  True
• Source Full Name:
  Health Physics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b413ad44fb69586a626273cdba6418c4394a79d805a29fdc503a79ae57003deee3697508f4e1fa0f6d71c9670239f11940f019e64472ff1a10233eca5834a1e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/185246/cdc_185246_DS1.pdf
• File Type:
  [PDF - 366.90 KB ]