The effects of sulfur dioxide on pulmonary function in healthy nonsmoking male subjects aged 55 years and older.

Details

• Personal Author:
  Koenig JQ ; Marshall SG ; Rondinelli RC
• Description:
  The effects of respired sulfur-dioxide (7446095) on pulmonary function in 10 nonsmoking healthy male volunteers aged 55 to 73 years were examined. Subjects were exposed to 1.0 or 0.5 parts per million (ppm) sulfur-dioxide in sodium-chloride (NaCl) droplet aerosol or to aerosol alone, while at rest for 20 minutes and during moderate exercise on a treadmill for 10 minutes. The NaCl droplet aerosol was at a particle mass concentration of 1mg/m3. Respiration of sulfur-dioxide at a dose of 1.0 part per million significantly enhanced the reduction in forced expiratory volume over that observed following respiration of NaCl aerosol only. Thus sulfur- dioxide at the level of 1ppm produced a decrement in forced expiratory volume beyond the exercise induced bronchoconstriction following normal saline exposure. When these data were compared to an historical profile obtained from healthy adolescent males, a moderate increase in sensitivity to respired sulfur-dioxide was observed. Subjects filled out a symptom rating form to record subjective reactions immediately after exposure, on the test day and on the next day. There were no consistent differences in symptom rating between NaCl aerosol exposure and sulfur-dioxide in NaCl aerosol. [Description provided by NIOSH]
• Subjects:
  Age Factors Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Environmental Exposure Occupational Exposure Occupational Health Safety
• Keywords:
  Acute-exposure Age-factors Air-contamination Air-quality Environmental-exposure Humans In-vivo-studies NIOSH-Grant NIOSH-Publication
• ISSN:
  0002-8894
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  299-303
• Volume:
  48
• Issue:
  4
• NIOSHTIC Number:
  nn:00169015
• Citation:
  Am Ind Hyg Assoc J 1987 Apr; 48(4):299-303
• CAS Registry Number:
  Sulfur dioxide (CAS RN 7446-09-5)
• Federal Fiscal Year:
  1987
• NORA Priority Area:
  Work Environment and Workforce: Special Populations
• Performing Organization:
  Environmental Health University of Washington Environmental Health Dept Seattle, Wash 98195
• Peer Reviewed:
  True
• Start Date:
  19770930
• Source Full Name:
  American Industrial Hygiene Association Journal
• End Date:
  19920630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:888910a677d5cf6882c7c98e25b99da31ad759c63857066a3bd13a88627103516964eac61ae2d92b46ae8049fcb6b91227adc7a09a19b2d05d3e9f601754752b
• Download URL:
  https://stacks.cdc.gov/view/cdc/185183/cdc_185183_DS1.pdf
• File Type:
  [PDF - 642.93 KB ]