Carcinogenic effects of antimony trioxide and antimony ore concentrate in rats.

Details

• Personal Author:
  Burg, Jeanne R. ; Busey WM ; Grant GC ; Groth DH ; Stettler, Lloyd E. ; Wong L
• Description:
  Approximately 450 male and 450 female Wistar derived albino rats were used to study the chronic effects of the inhalation of antimony- trioxide (7790445) (Sb2O3) and antimony (7440360) (Sb) ore concentrate. The incidence of lung neoplasms was 19/59, or 32 percent, for those animals examined after 53 weeks of the study. Sb- ore induced the same effect at about the same incidence. These findings support observations of an increased incidence of lung cancer in workers exposed during the refining of Sb-ore in the production of Sb2O3. Female rats were more susceptible to the induction of lung cancer by both agents. Tissues and blood of female rats contained higher concentrations of arsenic than the males. The lung concentration of arsenic was higher in males than females exposed to Sb2O3. Female rats had a higher incidence of pituitary tumors than males. Even though the Sb-ore contained much more arsenic than the Sb2O3, rats exposed to Sb2O3 carried 5 to 6 times as much arsenic in their lungs. The authors suggest this may have been due to the solubility of the arsenic in Sb-ore. Studies of worker exposure indicate that workers are exposed to levels quite near to those used in this study. The authors conclude that antimony compounds are carcinogenic and mutagenic. [Description provided by NIOSH]
• Subjects:
  Carcinogens Laboratories Lung Lung Diseases Metals Metal Workers Mutagens Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Carcinogenesis Contract-210-77-0156 Laboratory-animals Lung-cancer Lung-disorders Lung-irritants Mutagenesis NIOSH-Author NIOSH-Contract NIOSH-Publication Smelters Smelting

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• ISSN:
  0098-4108
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Missouri ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 7 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  4
• NIOSHTIC Number:
  nn:00163954
• Citation:
  J Toxicol Environ Health 1986; 18(4):607-626
• CAS Registry Number:
  Antimony (CAS RN 7440-36-0) ; Triiodostibine (CAS RN 7790-44-5)
• Federal Fiscal Year:
  1986
• Performing Organization:
  Midwest Research Institute, Kansas City, Missouri
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6a15067257825ce0653b06ddecca0237c718bb0ea34440b211fdbfa72ccaba5eefa0c569da6f8bcc3bc46cb246697cc5e3fc328b9b0b7f53929cb23ccaa9e05c
• Download URL:
  https://stacks.cdc.gov/view/cdc/185017/cdc_185017_DS1.pdf
• File Type:
  [PDF - 1.08 MB ]