Carcinogen bioassay of nitrous oxide in mice.

Details

• Personal Author:
  Baden JM ; Kosek JC ; Kundomal YR ; Luttropp ME Jr. ; Mazze RI
• Description:
  Male and female Swiss-Webster mice were exposed to either air (Group 1, n=179), 10 percent nitrous-oxide (10024972) (N2O) (Group 2, n=152), or 40 percent N2O (Group 3, n=151) for 4 hours per day, 5 days per week for 78 weeks followed by a 5 week nonexposure period. Surviving animals, and animals dying at earlier points, were subjected to complete autopsies. Mean body weights for Group 2 were similar to those in the control group, but Group 3 exhibited 5 percent lower body weights than controls after the 60th week of exposure for males and after the 40th week for females. Nonneoplastic lesions observed in the tissues were not related to treatment. There was no microscopic evidence of cellular damage nor evidence of megaloblastic changes or bone marrow depression. Most of the neoplastic lesions observed (the first appeared after 26 weeks of treatment) in control and test animals were either lung adenomas of alveolar cell origin or liver tumors of the basophilic hepatocellular adenoma type; there was no significant difference in the occurrence of tumors in control and exposed groups. Based on the results of this and other studies, the authors conclude that N2O has little or no carcinogenic potential. [Description provided by NIOSH]
• Subjects:
  Anesthesia Body Weight Carcinogens Hazardous Substances Histology Laboratories Nitrogen Compounds Nitrogen Oxides Nitrous Oxide Occupational Health Pathology Safety

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• Keywords:
  Anesthetics Author Keywords: Anesthetics Body-weight Carcinogenicity Gaseous Gases Laboratory-animals NIOSH-Grant NIOSH-Publication Nitrogen-compounds Nitrogen-oxides Nitrous-oxides Nitrous Oxide Rodents Toxicity

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• ISSN:
  0003-3022
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  6
• NIOSHTIC Number:
  nn:00163209
• Citation:
  Anesthesiology 1986 Jun; 64(6):747-750
• CAS Registry Number:
  Nitrous oxide (CAS RN 10024-97-2)
• Federal Fiscal Year:
  1986
• Performing Organization:
  Department of Anesthesiology Stanford University Stanford, Calif 94305
• Peer Reviewed:
  True
• Start Date:
  19820801
• Source Full Name:
  Anesthesiology
• End Date:
  19870731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc370949de3f77f668e5ef551787adc53adf0b1a99f3e5dd0d51ef9aa9888e1406aaf7bbfb57a9b825cbda1dab44d0b8e570569cb69a717a18905efa528f9eff
• Download URL:
  https://stacks.cdc.gov/view/cdc/184986/cdc_184986_DS1.pdf
• File Type:
  [PDF - 312.86 KB ]