Prevalence of IgE antibodies to grain and grain dust in grain elevator workers.

Details

• Personal Author:
  Lewis, Daniel M. ; Olenchock, Stephen A. ; Romeo PA
• Description:
  A survey of the prevalence of immunoglobulin-E (IgE) antibodies in grain elevator workers (SIC-5153) was conducted. The radioallergosorbent test (RAST) was performed on 175 samples of sera obtained from grain terminal workers as part of a NIOSH sponsored cross sectional study on the health effects of grain dust using aqueous extracts of commercial allergens prepared from grain and work site allergens from samples collected at the work site. The RAST assays were performed using the grain dusts bound to cellulose discs as supplied in commercial kits or bound to cellulose beads. Skin testing using extracts of the same dusts was performed for comparison purposes. The two RAST assays produced a significant discordance in the results. The RAST assay using extracts bound to cellulose beads generally produced a higher prevalence of positive reactions than the commercial disc method. This was taken to mean that the two RAST assays were measuring two different IgE specificities. The RAST assay using the bead method compared more favorably with the skin test data than the disc method. The authors conclude that aqueous extracts of grain dusts can be used as a course method for the RAST assay. The presence of IgE antibodies in response to occupationally associated antigens suggests that grain elevator workers may have an increased risk of developing respiratory problems. [Description provided by NIOSH]
• Subjects:
  Biological Assay Environmental Exposure Hazardous Substances Hypersensitivity Irritants Lung Lung Diseases Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Safety Workplace

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• Keywords:
  Allergens Analytical-methods Bioassays Health-hazards Industrial-exposures Lung-function NIOSH-Author Occupational-hazards Pulmonary-disorders Respiratory-irritants Workplace-studies

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• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  149-153
• Volume:
  66
• NIOSHTIC Number:
  nn:00158943
• Citation:
  Environ Health Perspect 1986 Apr; 66:149-153
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• NAICS and SIC Codes:
  5153 - Grain and field beans - (SIC)
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:abee49a94b52fc37883e4e110a902dd2e72873899f31e189b945c08be073650e761eaa76bbd78b1eb7dbc458ae13655c8cf7c39447aa2fcd691707629eb17b83
• Download URL:
  https://stacks.cdc.gov/view/cdc/184966/cdc_184966_DS1.pdf
• File Type:
  [PDF - 945.76 KB ]