Renal toxicity in uranium mill workers.

Details

• Personal Author:
  Baker, Dean B. ; Berl T ; Halperin, William E. ; Smith AB ; Steenland, Kyle ; Thun, Michael J.
• Description:
  The effects of long term soluble uranium (7440611) (yellowcake) exposure on the human kidney were investigated. Personnel records and employee committees were used to identify workers with past exposure to yellowcake. A total of 39 out of 42 uranium workers agreed to participate. To assess renal function, an 8 hour urine sample was collected from each worker over the workday and blood samples were drawn in the middle of the work shift. Serum and urinary beta-2-microglobulin were measured by radioimmunoassay. Serum and urinary creatinine were measured by an auto analyzer. The concentration of 26 amino acids was measured in the urine by ion exchange chromatography. Serum creatinine and creatinine clearance were used as markers of glomerular function. Renal excretion of beta- 2-microglobulin was used as an indicator of tubular reabsorption of low molecular weight proteins. The excretion of beta-2- microglobulin in the urine was significantly higher among the uranium workers. The variable which best predicted beta-2- microglobulin clearance relative to creatinine clearance was the length of time the employee had worked in the yellowcake area. The mean amino acid excretion of 22 out of 23 amino acids was higher among uranium workers than comparisons. Serum concentration of beta- 2-microglobulin was significantly higher among uranium workers than comparisons. The authors conclude that low concentrations of beta-2- microglobulin and aminoaciduria are found in workers exposed to yellowcake. [Description provided by NIOSH]
• Subjects:
  Metals Occupational Health Safety Toxicology Workload Workplace
• Keywords:
  Author Keywords: Beta-2-microglobulin Chemical Toxicity Nephrotoxicity NIOSH-Author Renal-absorption Renal-toxicity Renal Effects Trace-analysis Trace-metals Trace-substances Uranium Uranium Mining And Milling Work-analysis Work-capacity Work-environment Work-performance Workplace-studies

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• ISSN:
  0355-3140
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; Ohio ; OSHA Region 5 ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  83-90
• Volume:
  11
• Issue:
  2
• NIOSHTIC Number:
  nn:00150274
• Citation:
  Scand J Work Environ Health 1985 Apr; 11(2):83-90
• Contact Point Address:
  Dr MJ Thun, National Institute for Occupational Safety and Health, R-16, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
• CAS Registry Number:
  Uranium (CAS RN 7440-61-1)
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  True
• NAICS and SIC Codes:
  1094 - Uranium-radium-vanadium ores - (SIC)
• Source Full Name:
  Scandinavian Journal of Work, Environment & Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a7565c400b1cc451f5a57b33edd8da89f671c9bc8e09a974761139b201ce34d6160d57a50983691b022d380a642dd4316af83d10932ff8dec5eb6bdb734a7001
• Download URL:
  https://stacks.cdc.gov/view/cdc/184869/cdc_184869_DS1.pdf
• File Type:
  [PDF - 5.48 MB ]