Phototoxicity occurring during the manufacture of ultraviolet-cured ink.

Details

• Personal Author:
  Emmett, Edward A. ; Kominsky, John R. ; Taphorn BR
• Description:
  Complaints of photosensitivity in ultraviolet (UV) cured ink workers (SIC-2899) were investigated. Four white males, aged 26 to 52 years, were studied. Their jobs were to weigh, mix, or mill the UV cured ink. Clinical characteristic, after sun exposure were burning or smarting and erythema and swelling, with durations up to several days. Eczematous dermatitis, an allergic contact sensitization to acrylates, was seen in two of the workers. The UV absorption spectra of all ingredients of the ink were determined by a spectrophotometer. Ingredients absorbing UV radiation over 290 nanometers (nm) were evaluated for phototoxicity in an Ehrlich ascites cell system. Photopatch testing was performed on three employees complaining of photosensitivity and four free of photosensitivity. In-vivo phototoxicity and photoprotection tests were done. Protection was patch tested with 5 percent p- aminobenzoic-acid (150130) and 10 percent sulisobenzone (4065456). Photoinitiators found to absorb UV radiation above 250nm were benzophenone (119619), thioxanthone (492228), 2,2- diethoxyacetophenone (6175457), Michler's ketone or 4,4'- bis(dimethylamino)benzophenone (90948). Phototoxicity assay showed that Michler's ketone, thioxanthone, and the two absorbers were phototoxic. Only the absorbers proved phototoxic in in-vivo patch tests. Phototesting demonstrated diphasic reactions in both sensitive and non sensitive employees. The prior application of 5 percent p-aminobenzoic-acid provided partial protection, but 10 percent sulisobenzone completely suppressed the phototoxic response. The authors suggest that a 10 percent sulisobenzone preparation may be a useful sunscreen for use in accidental skin contamination. [Description provided by NIOSH]
• Subjects:
  Dermatitis Ink Occupational Exposure Occupational Health Personal Protective Equipment Printing Safety Skin Skin Diseases
• Keywords:
  Biological-effects Employee-exposure Industrial-chemicals Medical-treatment NIOSH-Author Occupational-dermatitis Occupational-exposure Photochemical-reactions Printing-inks Protective-measures Skin-exposure Skin-irritants

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• ISSN:
  0003-987X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  113
• Issue:
  6
• NIOSHTIC Number:
  nn:00149649
• Citation:
  Arch Dermatol 1977 Jun; 113(6):770-775
• CAS Registry Number:
  2,2-Diethoxyacetophenone (CAS RN 6175-45-7) ; 4,4′-Bis(dimethylamino)benzophenone (CAS RN 90-94-8) ; 4-Aminobenzoic acid (CAS RN 150-13-0) ; Benzophenone (CAS RN 119-61-9) ; Benzophenone 4 (CAS RN 4065-45-6) ; Thioxanthone (CAS RN 492-22-8)
• Federal Fiscal Year:
  1977
• Performing Organization:
  Pan American Health Organization
• Peer Reviewed:
  True
• NAICS and SIC Codes:
  2899 - Chemical preparations, not elsewhere classified - (SIC)
• Source Full Name:
  Archives of Dermatology
• End Date:
  19660930
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:28e7d8aaa13ce34db63f0649efce64d38cb30ddfafcd857bd3b86b462e634d62b40cda83ace969da31b23bc9041130e3648bb4ba34a65eee874282b47a081418
• Download URL:
  https://stacks.cdc.gov/view/cdc/184866/cdc_184866_DS1.pdf
• File Type:
  [PDF - 738.88 KB ]