Effects of alcohol, caffeine and methyl chloride on man.

Details

• Personal Author:
  Croxton JS ; Putz-Anderson, Vernon ; Setzer JV
• Description:
  The effects of caffeine (58082), ethanol (64175) and methyl-chloride (74873) were examined in humans. Each participant underwent several tests: dual task; time discrimination; visual vigilance; and dual task and time discrimination. Participant pairs were tested in a controlled environment, seated at a desk in front of a remote, computer controlled cathode ray tube. Pure methyl-chloride was administered from a pressurized cylinder. Room concentrations of methyl-chloride were measured by infrared spectrophotometry and gas chromatography. A dose of 0.8 milligram per kilogram (mg/kg) absolute ethanol was administered in the form of a drink. Caffeine was administered in capsule form at 3mg/kg. Alveolar breath samples for both methyl-chloride and ethanol were collected hourly. Venous blood samples were obtained prior to exposure and 90 minutes after exposure. Within 30 minutes after exposure, the average concentration of methyl-chloride was 199 parts per million. Alcohol and caffeine, when administered independently, produced significant changes in performance. The expected improvement due to caffeine was weak in comparison to the effect of alcohol, which produced systematic impairments on almost all of the test indices. When caffeine and ethanol were administered in conjunction with solvent exposure, the combined result was essentially equivalent to the effect of each agent alone. The authors conclude that the effects of caffeine or alcohol are not enhanced by methyl-chloride. [Description provided by NIOSH]
• Subjects:
  Halothane Occupational Health Safety Solvents Toxicology
• Keywords:
  Biological-effects Comparative-toxicology Depressants Drug-interaction Halogenated-hydrocarbons Industrial-chemicals Industrial-equipment Medical-research Organic-chemicals Stimulants
• ISSN:
  0033-2941
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  48
• NIOSHTIC Number:
  nn:00149595
• Citation:
  Psychol Rep 1981 Jan; 48:715-725
• CAS Registry Number:
  Caffeine (CAS RN 58-08-2) ; Ethanol (CAS RN 64-17-5) ; Methyl chloride (CAS RN 74-87-3)
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  True
• Source Full Name:
  Psychological Reports
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:63c73f45be17a9200604c34bc101815af14c0374d2b8a8e6737f666426a9b822753c51fcc1423a1f8f0650114411ad6c410f10d49872da56a5e64ae6ab6cc8a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/184865/cdc_184865_DS1.pdf
• File Type:
  [PDF - 415.33 KB ]