Pulmonary function evaluation of cats after one year of exposure to diesel exhaust.

Details

• Personal Author:
  Clark JC ; Mattox J ; Moorman WJ ; Pepelko WE ; Clark JC ; Mattox J ; Moorman WJ ; Pepelko WE
• Description:
  The effects of diesel exhaust emissions upon pulmonary function were studied in cats. Young adult male cats were exposed to diesel particulates at a concentration of 6 milligrams per cubic meter 8 hours per day, 7 days per week for 1 year. After 1 year, the animals were removed from the chamber and pulmonary function tests were conducted. Pulmonary function parameters evaluated included lung volume, forced expiratory flow rates, dynamic compliance and resistance, diffusing capacity, and nitrogen washout. No significant changes in pulmonary function parameters were detected except for a decrease in closing volume. The authors note that the decrease in closing volume cannot be interpreted as an impairment, as it indicates improved function of the small airways. The effect is probably a statistical error, arising from the large inter/animal variation seen in some of the pulmonary function tests. The authors conclude that inhalation of diesel exhausts under the experimental conditions does not cause functional changes in the lungs of cats. The exposed cats may have functionally adapted to the exposure. [Description provided by NIOSH]
• Subjects:
  Animals Environmental Exposure Environmental Monitoring Environmental Pollution Inhalation Exposure Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Animal-studies Environmental-health-monitoring Environmental-pollution Exhaust-systems Exposure-levels Health-standards Inhalants Physiology Pulmonary-congestion Respiration
• Publisher:
  U.S. Environmental Protection Agency
• Document Type:
  Text
• Genre:
  Proceedings ; Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences ; DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  2
• NIOSHTIC Number:
  nn:00148988
• Citation:
  Health effects of diesel engine emissions: proceedings of an international symposium, December 3-5, 1979. Pepelko WE, Danner RM, Clarke NA, eds. Cincinnati, OH: U.S. Environmental Protection Agency, EPA-600/9-80-057b, 1980 Nov; 2:757-765
• Editor(s):
  Pepelko WE; Danner RM; Clarke NA ; Pepelko WE; Danner RM; Clarke NA
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Source Full Name:
  Health effects of diesel engine emissions: proceedings of an international symposium, December 3-5, 1979
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:44bb814593dab33da50592320d683fc9ebf928b500eff47b59ff2886471a1eee4ab45ae3e9f132c457346a39e849541964981cda24ab8b4120d5acaadd4dae50
• Download URL:
  https://stacks.cdc.gov/view/cdc/184858/cdc_184858_DS1.pdf
• File Type:
  [PDF - 349.09 KB ]