A Study of Diesel Emissions on Drosophila [1980]

Details

• Personal Author:
  Niemeier RW ; Schuler RL
• Description:
  The mutagenic effects of diesel exhaust emissions were studied in Drosophila-melanogaster fruit flies. Male Drosophila flies were exposed to a five fold dilution of exhaust from a diesel engine for 8 hours. The flies were allowed to mate. A sex linked recessive lethal study was performed on broods of the F2 and F3 generations. Samples of the atmosphere in the exposure chamber were analyzed. The composition of the exposure chamber atmosphere was: carbon- dioxide (124389), 0.17 percent; carbon-monoxide (630080), 12.2 parts per million (ppm); total hydrocarbons, 11.6ppm; sulfur-dioxide (7446095), 1.0ppm; nitric-oxide (10102439), 3.8ppm; nitrogen-dioxide (10102440), 2.9ppm; and particulates, 2.2 milligrams per cubic meter. The incidence of mutations in the exposed F2 broods was 0.30 percent and in the controls, 0.37 percent. The mutation frequency in the exposed F3 generation was 0 percent and in the controls, 0.15 percent. The overall incidence (F2 plus F3) of mutants was: exposed flies, 0.20 percent; controls, 0.29 percent. The authors conclude that under the conditions of the experiment, diesel exhaust emissions are not mutagenic. They recommend repeating the experiment with higher exposure concentrations and longer exposures. [Description provided by NIOSH]
• Subjects:
  Carcinogens Environmental Exposure Environmental Monitoring Environmental Pollution Hazardous Substances Neoplasms Occupational Health Safety Vehicle Emissions
• Keywords:
  Cancer Carcinogenicity Diesel-exhausts Environmental-health-monitoring Environmental-pollution Exhaust-gases Exhaust-systems Exposure-levels Health-hazards Health-standards Physiology

  More +
• Publisher:
  U.S. Environmental Protection Agency
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2
• NIOSHTIC Number:
  nn:00148911
• Citation:
  Health effects of diesel engine emissions: proceedings of an international symposium, December 3-5, 1979. Pepelko WE, Danner RM, Clarke NA, eds. Cincinnati, OH: U.S. Environmental Protection Agency, EPA-600/9-80-057b, 1980 Nov; 2:914-923
• CAS Registry Number:
  Carbon dioxide (CAS RN 124-38-9) ; Carbon monoxide (CAS RN 630-08-0) ; Nitric oxide (CAS RN 10102-43-9) ; Nitrogen dioxide (CAS RN 10102-44-0) ; Sulfur dioxide (CAS RN 7446-09-5)
• Editor(s):
  Pepelko WE; Danner RM; Clarke NA
• Federal Fiscal Year:
  1981
• Peer Reviewed:
  False
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8e7d26e75a57a5ca14572d7c2a069b2ca34b9689e9119fc22935ca90bdd04795a6c7e090c3a57ac28934dd0c0ca35e10a368f5b2d370b6dd83b763afc67d140c
• Download URL:
  https://stacks.cdc.gov/view/cdc/184855/cdc_184855_DS1.pdf
• File Type:
  [PDF - 589.51 KB ]