Estimates of dose-response for respiratory cancer among chrysotile asbestos textile workers.

Details

• Personal Author:
  Dement, John M. ; Harris RL Jr. ; Shy C ; Symons MJ
• Description:
  Dose response relationships for lung cancer and respiratory diseases not malignant were studied among chrysotile (12001295) asbestos (1332214) textile workers. The cohort mortality study included 768 males employed 6 or more months in textile production. Cause specific standardized mortality ratios were calculated using a life table analysis. For evaluating dose response, cumulative exposure strata were created; a worker moved from one stratum to the next if cumulative exposure increased during the course of followup. Linear models were developed to allow estimation of worker exposures in each exposure zone over time. Statistically significant excess mortality was observed for lung cancer and respiratory diseases not malignant. The elevated mortality ratio for all malignant neoplasms resulted from cancer of the trachea, bronchus, and lung. There were 15 deaths attributed to asbestosis or pulmonary fibrosis. Lung cancer mortality ratio increased with duration of employment. No asbestosis or lung cancer deaths occurred among subjects prior to 15 years after intial employment. Of the 191 deaths reported, only 1 was due to mesothelioma. Statistically significant mortality ratio excesses were observed for all high dust exposure groups, excluding acute upper respiratory infection, influenza, pneumonia, and bronchitis. The authors conclude that there is a strong dose response linear relationship for both lung cancer and respiratory diseases in chrysotile asbestos textile workers. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Epidemiology Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Safety Workplace
• Keywords:
  Airborne-fibers Analytical-models Disease-incidence Employee-exposure Industrial-medicine Mathematical-models NIOSH-Author Occupational-medicine Occupational-respiratory-disease Risk-analysis Work-environment

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• ISBN:
  9780080268385
• ISSN:
  0003-4878
• Publisher:
  Pergamon Press
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  1
• NIOSHTIC Number:
  nn:00141891
• Citation:
  Ann Occup Hyg, Inhaled Particles V, 1982 Sep; 26(1-4):869-887
• Contact Point Address:
  J. M. Dement, National Institute for Occupational Safety and Health, Morgantown, West Virginia, U.S.A.
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5)
• Editor(s):
  Walton WH
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Occupational Hygiene, Inhaled Particles V
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ca937af67931455929e5abddc8f616ff68ec9873fae5681a4e1abd29f3bbc642654911e9b7512e374c4184134f4da925c69e2a1751ff4b1a3459c04c3aa6ca79
• Download URL:
  https://stacks.cdc.gov/view/cdc/184767/cdc_184767_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]