Pulmonary function responses in cats following long-term exposure to diesel exhaust.

Details

• Personal Author:
  Clark JC ; Mattox J ; Moorman WJ ; Pepelko WE
• Description:
  Physiological effects of long term inhalation of diesel emissions were investigated in cat lungs. During the first 61 weeks of exposure, the exhaust was diluted to produce a particulate concentration of 6 milligrams per cubic meter (mg/m3). For the balance of exposure, it was adjusted to produce a concentration of 12mg/m3. The animals were exposed 8 hours per day, 7 days per week, for 2 years. Pulmonary mechanical properties were measured. Following the first 61 weeks of exposure, no significant patterns of response were found in mechanical properties, diffusing capacity, uniformity of distribution, or ventilatory performance. A clearly defined response existed at the end of 124 weeks of exposure. The reduction in inspiratory capacity, vital capacity, and total lung capacity with normal values for dynamic ventilatory function indicated a lesion that restricted breathing but did not cause airway obstruction. This restrictive disease was compatible with a diagnosis of pulmonary fibrosis of the interstitial or intraalveolar type. Additional support for the diagnosis was the finding of impaired diffusing capacity. The authors conclude that adverse pulmonary responses occur with high concentrations of diesel emission. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Cats Breathing-atmospheres Diesel Exhaust Exposure-levels Exposure-limits Laboratory-animals NIOSH-Author Pulmonary-disorders Pulmonary-function Pulmonary Function Tests Respiration Toxic-effects Toxic-materials

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• ISSN:
  0260-437X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  301-305
• Volume:
  5
• Issue:
  5
• NIOSHTIC Number:
  nn:00136478
• Citation:
  J Appl Toxicol 1985 Oct; 5(5):301-305
• Contact Point Address:
  William J. Moorman, National Institute for Occupational Safety and Health Division of Biomedical and Behavioral Science, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
• Federal Fiscal Year:
  1986
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Applied Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eb4eaca968c7560fb593417615a3ec479496f4cb342f3d0ffd6021099d8c9e6307ff235904bbed1a5ba5675ce3b383d40e25ff4f95001ff719c127862713d867
• Download URL:
  https://stacks.cdc.gov/view/cdc/184693/cdc_184693_DS1.pdf
• File Type:
  [PDF - 449.18 KB ]