Determining the role of pulmonary fibrosis in the etiology of lung cancer.

Details

• Personal Author:
  Eldridge SR ; Renne RA ; Stevens DL
• Description:
  The effects of four particulate materials on the production of pulmonary fibrosis was studied in hamsters. Four doses of quartz (14808607) ranging from 0.03 to 6.0 milligrams (mg), a 1 to 1 mixture of quartz and ferric-oxide (1309371) at 0.03 to 6.0mg each, (1333842) were given to Syrian-Golden-hamsters in 15 weekly intratracheal instillations. Saline control and caged control hamsters were also maintained. Mortality and histopathologic evidence of pulmonary fibrosis were recorded. Mortality in the saline control group was similar to that in the caged controls. Among the four dose groups for each test material, dose related mortality rates were evident only in animals receiving 6.0 or 3.3mg quartz per week, or 6.0 or 3.3mg each of quartz and ferric-oxide. Survival of these animals was significantly decreased. Survival of animals receiving 2.0 or 0.2mg hydrated alumina was significantly decreased, but not dose dependent. Alveolar septal fibrosis was produced in all experimental groups at rates and at greater severity than in control animals. In general, increased doses of quartz or quartz/ferric-oxide produced fibrosis of greater severity and higher incidence. Incidence and severity of septal fibrosis in groups exposed to fibrous glass or hydrated alumina were not clearly dose related. However, the groups exposed to the highest doses of either material (10.0mg fibrous glass and 20.0mg hydrated alumina) had the highest incidence of septal fibrosis. The pulmonary fibrotic response to fibrous glass or hydrated alumina was much less striking than the response to quartz/ferric-oxide or to quartz alone. The authors suggest that development of an animal model to study the role of pulmonary fibrosis in lung cancer should be based on the use of multiple instillations of quartz in rats. Quartz produces pronounced pulmonary fibrosis and is less likely to increase mortality significantly in rats than in hamsters. [Description provided by NIOSH]
• Subjects:
  Animals Biological Factors Hazardous Substances Lung Lung Diseases Mortality Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal-studies Biological-effects Biological-factors Contract-210-79-0038 Disease-incidence Dose-response Mortality-data NIOSH-Contract Pulmonary-disorders Toxic-effects
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  Ohio ; OSHA Region 10 ; OSHA Region 5 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-73
• NIOSHTIC Number:
  nn:00130623
• NTIS Accession Number:
  PB83-244301
• Citation:
  NIOSH 1982 Mar; :1-73
• CAS Registry Number:
  Aluminum oxide (Al2O3), hydrate (CAS RN 1333-84-2) ; Iron oxide (Fe2O3) (CAS RN 1309-37-1) ; Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1982
• Performing Organization:
  Battelle Pacific Northwest Laboratories, Richland, Wasington
• Peer Reviewed:
  False
• Source Full Name:
  Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42fb3da015531d767c553f5a6d0e8dd85f1c882775d681297da5dd843016b724a291f34a9a2eab15faa538015e110c645ecd9481b0de4d65659fda6812b9f4bf
• Download URL:
  https://stacks.cdc.gov/view/cdc/184622/cdc_184622_DS1.pdf
• File Type:
  [PDF - 2.67 MB ]