Activation of the alternative pathway of complement by grain. I. C3PA conversion and quantification of complement consumption by rye.

Details

• Personal Author:
  Elliott JA ; Gladish ME ; Major, Pervis C. ; Mentnech MS ; Mull JC ; Olenchock, Stephen A. ; Peach MJ III ; Pearson DJ
• Description:
  The possible relationships between grain dust and activation of the alternative pathway of complement were addressed. Ground rye and airborne rye dust were added to normal human serum after particle size measurements were made. Reaction mixtures were incubated and tested for conversion of proactivator of the third component of complement (C3PA) to the active form (C3A), and for hemolytic complement activity (CH). Both rye samples, which were of similar size, with 70 to 75 percent of the particles being less than 10 microns, activated C3PA conversion to C3A with a dose response effect over concentration of 0.1 to 20 milligrams (mg). Airborne rye (5mg) consumed 100 percent of CH, while 5mg ground rye consumed 47 percent. The authors conclude that rye dust has the potential to activate complement in a dose dependent manner in both sensitized and nonsensitized individuals. [Description provided by NIOSH]
• Subjects:
  Agriculture Air Pollutants, Occupational Dust Hazardous Substances Irritants Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Airborne-dusts Airborne-particles Grain-elevator-workers Lung-irritants NIOSH-Author Particulates Respiratory-irritants Respiratory-system-disorders Toxic-materials
• ISSN:
  0009-9090
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  125-133
• Volume:
  8
• Issue:
  2
• NIOSHTIC Number:
  nn:00127371
• Citation:
  Clin Allergy 1978 Mar; 8(2):125-133
• Federal Fiscal Year:
  1978
• NORA Priority Area:
  Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Clinical Allergy
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6dbc7a90e09ae10b0505e34af58e42f0ee4777cd7390aeb90f6581271f5b0bc816670d8ca5557073da7791725d12817455515a52a86cfb98a3478d3cd06dad2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/184595/cdc_184595_DS1.pdf
• File Type:
  [PDF - 2.45 MB ]