Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Schrauwen, Eefje J.A. ; Herfst, Sander ; Chutinimitkul, Salin ; Bestebroer, Theo M. ; Rimmelzwaan, Guus F. ; ... More +
Schrauwen, Eefje J.A. ; Herfst, Sander ; Chutinimitkul, Salin ; Bestebroer, Theo M. ; Rimmelzwaan, Guus F. ; Osterhaus, Albert D.M.E. ; Kuiken, Thijs ; Fouchier, Ron A.M. Less -
Description:
Since emergence of the pandemic (H1N1) 2009 virus in April 2009, three influenza A viruses-seasonal (H3N2), seasonal (H1N1), and pandemic (H1N1) 2009-have circulated in humans. Genetic reassortment between these viruses could result in enhanced pathogenicity. We compared 4 reassortant viruses with favorable in vitro replication properties with the wild-type pandemic (H1N1) 2009 virus with respect to replication kinetics in vitro and pathogenicity and transmission in ferrets. Pandemic (H1N1) 2009 viruses containing basic polymerase 2 alone or in combination with acidic polymerase of seasonal (H1N1) virus were attenuated in ferrets. In contrast, pandemic (H1N1) 2009 with neuraminidase of seasonal (H3N2) virus resulted in increased virus replication and more severe pulmonary lesions. The data show that pandemic (H1N1) 2009 virus has the potential to reassort with seasonal influenza viruses, which may result in increased pathogenicity while it maintains the capacity of transmission through aerosols or respiratory droplets.
Subject:
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Animals
Cell Line
Ferrets
Humans
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H3N2 Subtype
Orthomyxoviridae Infections
Pandemics
Reassortant Viruses
Respiratory System
Seasons
Severity Of Illness Index

Source:
Emerg Infect Dis. 17(2):200-208.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:6e65f3d0f933c6488b0ef890cdb162a3cf2ee2b3be0341ecfe8332257f3d6456
File Type:

Supporting Files

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