Electron microscopic observations of hepatic and subcutaneous hemangiosarcomas induced in mice exposed to vinyl chloride monomer.

Details

• Personal Author:
  Suzuki Y
• Description:
  The ultrastructural characteristics of tumors induced in mice by vinyl-chloride (75014) were studied. Male mice were exposed by inhalation to 0 to 600 parts per million vinyl-chloride for 4 weeks. Animals were killed 0 to 65 weeks after exposure, and tissues were examined by electron microscope. Hemangiosarcomas and, more frequently, alveologenic tumors were induced. There was no ultrastructural difference between hemangiosarcomas induced by vinyl- chloride and those not related to exposure to this chemical. Although a clear dose dependence was not seen in hemangiosarcoma induction, the induction of alveologenic tumors was clearly dose related. The author concludes that in the mouse the alveolar epithelium is more sensitive than the capillary endothelium to the carcinogenicity of vinyl-chloride. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chlorine Compounds Laboratories Occupational Health Safety Vinyl Chloride
• Keywords:
  Author Keywords: Vinyl Chloride Carcinogenesis Chlorinated-ethylenes Dose-response Electron Microscope Studies Of Hemangiosarcoma Hepatic Hemangiosarcoma Laboratory-animals NIOSH-Grant NIOSH-Publication Subcutaneous Hemangiosarcoma Tumorigenesis Ultrastructure Vinyl-plastics

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  103-117
• Volume:
  2
• Issue:
  2
• NIOSHTIC Number:
  nn:00121461
• Citation:
  Am J Ind Med 1981 Feb; 2(2):103-117
• Contact Point Address:
  Community Medicine Mount Sinai School of Med Fifth Avenue & 100Th Street New York, N Y 10029
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  1981
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19761201
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  19811130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1aa9b3a23523a9c8a10e4b77bd8db3216095a579ac799183b65e59d896c0b09341fe92ba425777d434e6a3f469600dcc90af2c559292c6c6d4f94d7a0eb30f07
• Download URL:
  https://stacks.cdc.gov/view/cdc/184521/cdc_184521_DS1.pdf
• File Type:
  [PDF - 658.43 KB ]