The effect of pulmonary edema on gas trapping in excised rat lungs.

Details

• Personal Author:
  Frazer DG ; Stengel PW ; Weber KC
• Description:
  The relationship between gas trapping in excised rat lungs and pulmonary edema was studied. Pulmonary edema was induced in male Long-Evans-rats by means of high inspiratory positive pressure breathing. The lungs were then inflated and deflated for six different sequences of four cycles each. Deflation was at an end expiratory pressure of positive 6, 4, 3, 2, 0, or negative 5 centimeters of water. The volume of gas trapped in the lungs was measured. Lungs with pulmonary edema trapped gas at more positive values of end expiratory pressure than normal lungs. The authors conclude that at more positive transpulmonary pressures, the airways in excised lungs close sooner than those in normal lungs. [Description provided by NIOSH]
• Subjects:
  Laboratories Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Airway Closure Excised Rat Lungs Foam In Lungs Laboratory-animals Lung-cancer Lung Pressure-volume Curves Meniscus Formation In Airways NIOSH-Author Pulmonary-function Respiratory-gas-analysis Respiratory-gas-transport Respiratory-gases

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• ISSN:
  0034-5687
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  325-333
• Volume:
  38
• Issue:
  3
• NIOSHTIC Number:
  nn:00118204
• Citation:
  Respir Physiol 1979 Dec; 38(3):325-333
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  True
• Source Full Name:
  Respiration Physiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:33a558e4c0f3c3ff37bf8209e13f5e9f0ecbc848a3f5bcbe47d80da18b84051dcc5df9b2755d3b08ab7d89428f2ac9318a7d8fe759504a0e33401c01e779f178
• Download URL:
  https://stacks.cdc.gov/view/cdc/184483/cdc_184483_DS1.pdf
• File Type:
  [PDF - 429.26 KB ]