Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney.

Details

• Personal Author:
  Clayton JW ; Gandolfi AJ ; Nagle R ; Potter CL
• Description:
  The renal toxic effect of inhaled chlorotrifluoroethylene (79389) (CTFE) and hexafluoropropene (116154) (HFP) was investigated in Fisher-rats. Rats were exposed to 100, 200 330, or 540 parts per million (ppm) of CTFE or 380, 470, 660, or 1200 ppm HFP for 4 hours. Control rats breathed air. After 4 hours rats were removed to metabolism cages and sacrificed at intervals up to 14 days after exposure. Urine and blood samples were biochemically analyzed and kidneys were prepared for histological examination. Within 2 days after exposure rats developed proximal tubular necrosis, diuresis, increases in urinary fluoride and lactic dehydrogenase (LDH), serum creatinine, and blood urea nitrogen. Pathological findings were directly proportional to the exposure dose. Diuresis was the most sensitive index of toxicity. Urinary LDH increases correlated with proximal tubular necrosis; increases were 100 times greater than normal values at the highest CTFE and HFP doses. At 100ppm, CTFE induced renal dysfunction but no LDH increase or necrosis was noted. All doses of HFP produced necrosis within 24 hours after exposure. The authors suggest that this acute toxicity data for CTFE and HFP will aid in the design of chronic toxicity studies. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biochemistry Hazardous Substances Histology Laboratories Occupational Health Pathology Safety Toxicology
• Keywords:
  Biochemical Analysis Kidney Disorders Kidney Necrosis Laboratory Animals Toxic Gases
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arizona ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  431-440
• Volume:
  59
• Issue:
  3
• NIOSHTIC Number:
  nn:00116265
• Citation:
  Toxicol Appl Pharmacol 1981 Jul; 59(3):431-440
• Contact Point Address:
  J. W. Clayton, Ph.D., Toxicology Program, University of Arizona, Tucson, Ariz. 85724
• CAS Registry Number:
  Chlorotrifluoroethylene (CAS RN 79-38-9) ; Hexafluoropropylene (CAS RN 116-15-4)
• Federal Fiscal Year:
  1981
• Performing Organization:
  University of Arizona
• Peer Reviewed:
  True
• Start Date:
  19820701
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19850630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ab805a9d18a7079dc32d7f055ec6b59723c00bac4e69607e69bdf6b31f36a6c469677a55f162fcbd9200052402df7d696845d697cae9855420ed024229bf508c
• Download URL:
  https://stacks.cdc.gov/view/cdc/184452/cdc_184452_DS1.pdf
• File Type:
  [PDF - 904.29 KB ]