Effects of inhaled endotoxin-containing bacteria.

Details

• Personal Author:
  Burrell R ; DeMaria TF
• Description:
  The pulmonary effects of endotoxin containing bacteria were studied in rabbits of either sex. Unimmunized rabbits were challenged with 5.0 milliliters of viable Escherichia-coli cells without envelope antigens. Changes in arterial blood gases, leukocytes, platelets and the peripheral complement were monitored as indices of inhalation response. Purified endotoxin and heat treated E-coli cells were used for a single challenge and consistent elevation in arterial oxygen tensions (PaO2) with concurrent depressions in PaO2 were observed 4 hours after challenge. Animals had leukocytosis after challenge which continued for up to 4 hours. There was no evidence of fever. Significant decreases in PaO2 occurred several hours after challenge and persisted for 8 hours. A decline in the circulating platelets coincided with depressed PaO2. Hemorrhagic lung injury resulted in the death of some of the experimental animals. Among the animals that survived, PaO2 values returned to normal in 24 hours. Indomethacin effectively inhibited the changes observed following a dual challenge. The authors suggest that common endotoxin containing microorganisms cause pulmonary reactions in at least two ways. The prevalence of gram negative organisms facilitates pulmonary injury in persons subject to a variety of occupational exposures. [Description provided by NIOSH]
• Subjects:
  Endotoxins Immune System Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Immunology Laboratory-animals Lung-disorders Lung-irritants NIOSH-Grant NIOSH-Publication Pulmonary-function Pulmonary-system-disorders
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  87-97
• Volume:
  23
• Issue:
  1
• NIOSHTIC Number:
  nn:00105616
• Citation:
  Environ Res 1980 Oct; 23(1):87-97
• Contact Point Address:
  Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
• Federal Fiscal Year:
  1981
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Environmental Research
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16acea842f52623a16c76863687878763ae94f8b16dac3c012b8240545d514927acf5c52b7e735691d2c5b6c67751d95efdd5669a0f3e2b8309c2275b915f0d4
• Download URL:
  https://stacks.cdc.gov/view/cdc/184378/cdc_184378_DS1.pdf
• File Type:
  [PDF - 758.19 KB ]