Sensory irritation by toluene diisocyanate in single and repeated exposures.

Details

• Personal Author:
  Alarie Y ; Sangha GK
• Description:
  The toxicity of toluene-diisocyanate (26471625) (TDI) was evaluated. Changes in respiratory rate were measured in mice exposed for 10 to 240 minutes to 0.007 to 2.0 parts per million (ppm) TDI vapor. Cumulative effects were tested in rats exposed to 0.007 to 1.18ppm TDI vapors 3 hours daily for 5 days. The severity of response and speed of recovery were dependent on exposure concentrations and duration of exposure. Repeated exposures to TDI at or above the threshold limit value for industrial exposure to TDI be reduced from the present 0.02ppm to 0.006ppm as a time weighted average and that no exposure above 0.02ppm be permitted. [Description provided by NIOSH]
• Subjects:
  Chemistry Laboratories Occupational Health Respiratory Function Tests Respiratory Tract Diseases Safety
• Keywords:
  Chemical-analysis Exposure-methods Laboratory-animals NIOSH-Grant NIOSH-Publication Pulmonary-function-tests Pulmonary-system-disorders Standards Tolerance-threshold
• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  50
• Issue:
  3
• NIOSHTIC Number:
  nn:00105211
• Citation:
  Toxicol Appl Pharmacol 1979 Sep; 50(3):533-547
• Contact Point Address:
  Occupational Health University of Pittsburgh 130 DE Soto Street Pittsburgh, PA 15213
• CAS Registry Number:
  Toluene diisocyanate (CAS RN 26471-62-5)
• Federal Fiscal Year:
  1979
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19711001
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19860531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:81af772a7b6350d841852236a1c525872e00affed1f5d63b1b750fa2be69bfe87bcac6ad52f4cb2237a723fe80df39c2b71e83671c28f726f2d313fd1a07fc21
• Download URL:
  https://stacks.cdc.gov/view/cdc/184375/cdc_184375_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]