Serum immunoglobulin levels in coal workers' pneumoconiosis.

Details

• Personal Author:
  Hahon N ; Morgan WK ; Petersen, Martin R.
• Description:
  Serum immunoglobulin (Ig) levels were examined in 155 U.S. coal miners with pneumoconiosis. Seventy one males, (21 underground miners and 50 nonminers) with no evidence of pneumoconiosis served as a comparison group. The 155 miners were divided into 3 major divisions: those with Caplans Syndrome, those with progressive massive fibrosis, and those with simple pneumoconiosis. Radial immunodiffusion plates were used to quantitate serum concentrations of alpha-1-antitrypsin, complement component (C3) and IgA, IgM, IgG and IgD. Most differences noted in serum immunoglobulin levels and protein concentrations were between the 3 pneumoconiosis groups. Significantly higher serum immunoglobulin levels and protein concentrations were apparent in workers with pneumoconiosis when compared to those without the disease. Elevated levels of either serum immunoglobulins or proteins were not associated with bronchitic conditions among the workers. The authors conclude that inhalation of occupationally associated agents or dust may selectively stimulate components of the immunoglobulin systems. [Description provided by NIOSH]
• Subjects:
  Chemistry Occupational Exposure Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Analytical-instruments Analytical-methods Chemical-reactions Humans Immune-system Measurement-methods NIOSH-Author Occupational-exposure Respiratory-system-disorders Sample-preparation
• ISSN:
  0003-4878
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  165-174
• Volume:
  23
• Issue:
  2
• NIOSHTIC Number:
  nn:00097654
• Citation:
  Ann Occup Hyg 1980 Apr; 23(2):165-174
• Contact Point Address:
  W. K. C. Morgan, University Hospital, Department of Medicine, London, Ontario N6A 5A5, Canada
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Occupational Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ea6a44ddb6f34c2a103465e5a46d89c0472a52817e580486e9f83127b217c0feebdf1c4924262f73151b4c3c30aa353eb3f37d4eced9ec7ffe7bf7bc3b93aa8c
• Download URL:
  https://stacks.cdc.gov/view/cdc/184356/cdc_184356_DS1.pdf
• File Type:
  [PDF - 460.65 KB ]