Nonneoplastic effects of vinyl chloride in mouse lung.

Details

• Personal Author:
  Suzuki Y
• Description:
  Nonneoplastic effects in mouse lung were investigated by light and electron microscopy. Mouse lung tissue containing tumors caused by exposure to vinyl-chloride monomer (75014) was prepared for microscopy. Light microscopy showed proliferation and hypertrophy of the terminal bronchiolar cells and hypersecretion of the epithelial mucin in the goblet cells. Hyperplasia of alveolar epithelium and mobilization of alveolar macrophages were also observed. In electron microscope studies, Clara cells showed proliferation of the rough and smooth surfaced endoplasmic reticulum. Large and abnormally shaped mitochondria were seen and similar alterations were found in the ciliated cells. Submicroscopic changes in the pulmonary alveoli were also observed. The author suggests that the alveolar capillary endothelium and the septal cell probably are also affected by vinyl-chloride. [Description provided by NIOSH]
• Subjects:
  Laboratories Lung Lung Diseases Manufacturing And Industrial Facilities Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Cellular-reactions Chemical-factory-workers Dose-response Histopathology Laboratory-animals Lung-cancer NIOSH-Grant NIOSH-Publication Plastic-materials-and-resins Pulmonary-system-disorders
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  235-253
• Volume:
  21
• Issue:
  1
• NIOSHTIC Number:
  nn:00093490
• Citation:
  Environ Res 1980 Feb; 21(1):235-253
• Contact Point Address:
  Yasunosuke Suzuki, Environmental Sciences Laboratory, Department of Community Medicine, and Department of Pathology, Mount Sinai School of Medicine of the City University of New York, One Gustave Levy Place, New York. New York 10029
• CAS Registry Number:
  Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  1980
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19761201
• Source Full Name:
  Environmental Research
• End Date:
  19811130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c26f04e91f21240a0ae986c97480cb0c95a5cec72ba5e009005e9faed0af94f2074e87941651980f3432efecd3e5ddcfb95e1be086a5b268500b5d85126d5e8b
• Download URL:
  https://stacks.cdc.gov/view/cdc/184326/cdc_184326_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]