Analysis of total arsenic in urine and blood by high speed anodic stripping voltammetry.

Details

• Personal Author:
  Berlandi FJ ; Davis PH ; Dulude GR ; Griffin RM ; Matson WR ; Zink EW
• Description:
  A method for measuring parts per billion concentrations of total arsenic (7440382) (As) in urine and blood was formulated. Blood and urine samples were wet ashed with sulfuric-acid, nitric-acid, and perchloric-acid, then reductillated (reduced and distilled) to convert As(V) to As(III) and to separate the As(III) from other ions in the sample matrix. The resulting solution was then analyzed for its As content by anodic stripping voltammetry (ASV) at a gold film electrode. The accuracy of the technique was evaluated by analyzing several standards of known As content. The agreement between values obtained by the test method and accepted values for the standards was excellent. Recovery of arsenic from whole blood also was outstanding, and required only 4 milliliters for analysis. Percent recovery of As from urine was acceptable. The time required for reductillation of samples was 12 minutes, and 2 minutes were necessary for ASV analysis. By simultaneous reductillation of four samples, parts per billion arsenic determinations could be accomplished at the rate of approximately 12 per hour. The authors conclude that the reductillation/ASV procedure is as accurate, precise, and reliable at the nanogram level as the more universally accepted colorimetric techniques are at the microgram and milligram levels. [Description provided by NIOSH]
• Subjects:
  Blood Chemistry Hematologic Tests Occupational Health Safety Urine
• Keywords:
  Analytical-methods Blood-chemical-analysis Chemical-reactions Contract-099-72-0107 Detectors Electrochemical-analysis Electrochemical-equipment Industrial-poisons Measurement-instrumentation NIOSH-Contract NIOSH-Publication Reaction-products Urinalysis

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• ISSN:
  0002-8894
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  480-490
• Volume:
  39
• Issue:
  6
• NIOSHTIC Number:
  nn:00092690
• Citation:
  Am Ind Hyg Assoc J 1978 Jun; 39(6):480-490
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  1978
• Peer Reviewed:
  True
• Source Full Name:
  American Industrial Hygiene Association Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cd8400c223de728148f91cea96687f8e5547f455d1e6c4050ff8b97a81741508d39234f48286a9058cda355895032242a8eac1a86d4852b02c09c2c9bfa2eb39
• Download URL:
  https://stacks.cdc.gov/view/cdc/184307/cdc_184307_DS1.pdf
• File Type:
  [PDF - 454.90 KB ]