Electrodiagnostic study of the neurotoxicity of methyl n-amyl ketone.

Details

• Personal Author:
  Hornung, Richard W. ; Johnson BL ; Lewis TR ; Setzer JV
• Description:
  An electrodiagnostic study to determine the neurotoxicity in animals of methyl-n-amyl-ketone (110430) (MAK) is reported. Eight monkeys and 50 rats in each of the two groups were exposed to MAK at 100ppm and 1000ppm for 6 hour a day, 5 days a week, for 9 months. Electrodiagnostic methods revealed no measurable signs of neurotoxicity in the animals at either MAK exposure, and no changes in body weights. Gross pathology and histopathology indicated no adverse effects of MAK. It was concluded that MAK does not possess the neurotoxic properties found in methyl-n-butyl-ketone (591786). [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Butanones Hazardous Substances Occupational Health Safety
• Keywords:
  Air-contamination Chronic-toxicity Exposure-limits Ketones NIOSH-Author Physiology
• ISSN:
  0002-8894
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  39
• Issue:
  11
• NIOSHTIC Number:
  nn:00083589
• Citation:
  Am Ind Hyg Assoc J 1978 Nov; 39(11):866-872
• CAS Registry Number:
  2-Heptanone (CAS RN 110-43-0) ; 2-Hexanone (CAS RN 591-78-6)
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  True
• Source Full Name:
  American Industrial Hygiene Association Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc6bad50cb042b5a83e7a88bc39d9c8a41a0b2f592583cd82d044e3f76d152faf048edc6d9429bf18007c6978f7e973a01b20949293d44a314a554903b82a22b
• Download URL:
  https://stacks.cdc.gov/view/cdc/184259/cdc_184259_DS1.pdf
• File Type:
  [PDF - 372.17 KB ]