Production of thermophilic actinomycete-hay aerosols for use in experimental hypersensitivity pneumonitis.

Details

• Personal Author:
  Burrell R ; McCullough MJ
• Description:
  An investigation of the factors that influence the production of dense aerosols of micropolyspora faeni and thermoactinomyces vulgaris from hay cultures revealed that the density, freshness, and moisture content of the hay were important influences. Dry aerosols were produced under optimum conditions from hay cultures of either actinomycete and from sterile hay for inhalation challenges to unimmunized rabbits. Depressions in arterial oxygen tensions and hemolytic complement were monitored after such challenge. This investigation showed that hay cultures are capable of inciting a hypersensitivity like reaction in the lungs, even in the absence of immunization to the organisms contained within the hay, but the entire hypersensitivity reaction cannot be attributed to m-faeni and t-vulgaris alone. Hay itself or other microbial or chemical components appear to have some heat stable component that possibly contributes to the pathogenesis of the disease. [Description provided by NIOSH]
• Subjects:
  Aerosols Hematologic Tests Lung Microbiology Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Hematology Microorganisms NIOSH-Grant NIOSH-Publication Pulmonary-function Pulmonary-system-disorders
• ISSN:
  0099-2240
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  34
• Issue:
  6
• NIOSHTIC Number:
  nn:00077059
• Citation:
  Appl Environ Microbiol 1977 Dec; 34(6):715-719
• Contact Point Address:
  Robert Burrell, Department of Microbiology, West Virginia University Medical Center, Morgantown, West Virginia 26506
• Federal Fiscal Year:
  1978
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Applied and Environmental Microbiology
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:92f1baca20c4e86fcf094694cb7c78f5ef0fce7e1e2520114664ee6eaa754ef090d610b82f7372f9b1a38f29a0955400b32867c22edca8b992fb07eafd0fd277
• Download URL:
  https://stacks.cdc.gov/view/cdc/184227/cdc_184227_DS1.pdf
• File Type:
  [PDF - 940.79 KB ]