Chromosomal damage in men occupationally exposed to vinyl chloride monomer and other chemicals.

Details

• Personal Author:
  Dumont CR ; Gamble J ; Heath CW Jr. ; Waxweiler, Richard J.
• Description:
  Chromosome breakage was determined in 14 polyvinyl-chloride (9002862) (PVC) polymerization workers (presumed high exposure to vinyl-chloride (75014) monomer), 4 workers in PVC processing (presumed low exposure), 17 in rubber tire manufacturing (presumed negligible exposure) and in 4 employees at the Center for Disease Control not exposed directly to any laboratory chemicals, as part of a larger study designed to provide multiphasic medical screening data on men employed at a large rubber and plastics plant. Men in all three industrial categories had been employed 10 years or longer. No significant differences were found between the three worker groups, but breakage levels in all three groups were significantly increased over levels in the nonindustrial controls. Chromatid gaps comprised the majority (86 percent) of aberrations. That there were no significant differences in chromosome breakage between the three industrial categories with differences in exposure is considered to imply the presence of agents other than vinyl- chloride monomer capable of inducing chromosome breaks. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chromosomes Genetics Hydrocarbons Manufacturing And Industrial Facilities Mutagens Occupational Health Rubber Safety
• Keywords:
  Chemical-industry Chemical-industry-workers Chlorinated-hydrocarbons Chromosome-damage Genetic-disorders Hazards Mutagenicity NIOSH-Author Plastics-manufacturing Rubber-manufacturing-industry
• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  68-72
• Volume:
  14
• Issue:
  1
• NIOSHTIC Number:
  nn:00073065
• Citation:
  Environ Res 1977 Aug; 14(1):68-72
• CAS Registry Number:
  Poly(vinyl chloride) (CAS RN 9002-86-2) ; Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  1977
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:76e466e2d881c5d62155157fc2591d61d680931aeb524f821058e730c0ddc3cc32e1925c1198d4c4819cf5ec316a02dd4410f33f883ba44600771ef084971096
• Download URL:
  https://stacks.cdc.gov/view/cdc/184199/cdc_184199_DS1.pdf
• File Type:
  [PDF - 273.40 KB ]