Initial occupational exposure to lead: chromosome and biochemical findings.

Details

• Personal Author:
  Cambiaghi G ; Forni A ; Secchi GC
• Description:
  Serial chromosome and biochemical studies were carried out in 11 subjects before and during initial occupational exposure to moderate quantities of lead (7439921) fumes in a storage battery plant. The rate of abnormal metaphases, mostly with chromatid and one break chromosome aberrations, was approximately doubled after one month of work; it further increased after two months of work; remained in this range up to seven months of exposure; and then tended to decrease somewhat. Blood lead levels increased progressively in the first few months, then reached a steady state. Urinary lead and coproporphyrin levels increased sharply after one month of work, while urinary delta-aminolevulinic-acid (ALA) dehydratase (9036377) (ALAD) activity of red blood cells (RBCs) was reduced to almost 50 percent of the initial values after one month, decreased further in subsequent months, and remained decreased through the remainder of the study. (Grant No. R01-OH-00339) [Description provided by NIOSH]
• Subjects:
  Biochemistry Blood Chromosomes Hazardous Substances Hematologic Tests Manufacturing And Industrial Facilities Metals, Heavy Occupational Health Safety Urine
• Keywords:
  Battery-manufacturing-industry Biochemical-responses Blood-chemistry Chromosome-damage Dose-response Grants-other Heavy-metals Indicators NIOSH-Grant NIOSH-Publication Toxic-substances Urine-chemistry Workers

  More +
• ISSN:
  0003-9896
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maine ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  73-78
• Volume:
  31
• Issue:
  2
• NIOSHTIC Number:
  nn:00071124
• Citation:
  Arch Environ Health 1976 Mar; 31(2):73-78
• Contact Point Address:
  None Via S Barnaba, 8 20122 Milan, Italy 20122 Milano, Italy
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Porphobilinogen synthase (CAS RN 9036-37-7)
• Federal Fiscal Year:
  1976
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Milan, Milan, Italy
• Peer Reviewed:
  True
• Start Date:
  19710601
• Source Full Name:
  Archives of Environmental Health
• End Date:
  19731031
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d4a389ae05fd71e48d301676a8f412aa51528e33ed70104e7f4d3f8b71d895bb4d27bb9abe5c32d6fec56b9ae6a6ac6a032a2f3e56587eb72cd61d9513b18330
• Download URL:
  https://stacks.cdc.gov/view/cdc/184169/cdc_184169_DS1.pdf
• File Type:
  [PDF - 7.63 MB ]