Nickel-epidermal interactions: diffusion and binding.

Details

• Personal Author:
  Katz SA ; Samitz MH
• Description:
  To elucidate some of the variables associated with nickel (7440020) contact allergy, the diffusion of nickel through the epidermis and the binding of nickel to the epidermis were investigated. Diffusion of nickel-63 through the epidermis from solutions of surfactants was slight. Considerable amounts of nickel, however, were bound to the epidermis. An epidermis powder was prepared, and selected functional groups were inactivated by chemical means. The nickel uptake of these modified epidermis powders as compared to the untreated material indicates that carboxyl groups are involved in the binding of nickel to a greater extent than are amino groups. (Grant No. R01-OH-00303) [Description provided by NIOSH]
• Subjects:
  Biochemistry Chemistry Dermatitis Hypersensitivity Metals Metals, Heavy Occupational Health Poisoning Safety Skin Skin Absorption Skin Diseases

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• Keywords:
  Biochemical-reactions Carboxylic-acids Chemical-binding Chemical-groups Contact-dermatitis Heavy-metals Metal-poisoning NIOSH-Grant NIOSH-Publication Permeability Skin-disorders Skin-penetration

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  34-39
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:00070702
• Citation:
  Environ Res 1976 Feb; 11(1):34-39
• Contact Point Address:
  Medicine, Dermatology Univ of Pennsylvania Hospital Duhring Laboratory Building Philadelphia, PA 19104
• CAS Registry Number:
  Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  1976
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  University of Pennsylvania, Philadelphia, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  19701201
• Source Full Name:
  Environmental Research
• End Date:
  19751130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:92b614272ce088eefd9ad0f572e68465518a40fd596e3dd5627d9a3af5657c0a0efe564ac69c7fd8576c1be600c472621d3f7077b26322dd809319efb61b6ce5
• Download URL:
  https://stacks.cdc.gov/view/cdc/184162/cdc_184162_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]