Cytologic observations and cancer incidence following exposure to BCME.

Details

• Personal Author:
  Archer VE ; Johnson WM ; Lemen RA ; Saccomanno G ; Wagoner KJ
• Description:
  A hygiene survey was conducted among male employees of an anion- exchange resin production facility using bis(chloromethyl)ether (542881). Those employees with five or more years exposure to bis(chloromethyl)ether, BCME, had a statistically significant association with abnormal sputum cytology, or 34 percent as compared to 11 percent for uranium surface miners. A lung cancer incidence study was made of 136 male workers, 1955-1972; data are given on five cases of bronchogenic cancer. Other studies found similar incidences of lung cancer among BCME workers. Carcinogenicity of BCME was first demonstrated in mice and these results of occupational exposure studies indicate a need for prior animal testing of new chemicals. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chlorine Compounds Diagnosis Ether Hazardous Substances Mortality Occupational Health Safety
• Keywords:
  Alkylating-agents Carcinogenesis Chlorine-compounds Diagnostic-techniques Ethers Mortality-data NIOSH-Author Screening Toxic-substances
• ISBN:
  9780890720509
• ISSN:
  0077-8923
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Ohio ; OSHA Region 5 ; OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  71-80
• Volume:
  271
• Issue:
  1
• NIOSHTIC Number:
  nn:00056700
• Citation:
  Ann NY Acad Sci 1976 May; 271(1):71-80
• CAS Registry Number:
  Chloromethyl ether (CAS RN 542-88-1)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  True
• Source Full Name:
  Annals of the New York Academy of Sciences
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f8da0848c4b4c25ceaed66d37edcded00ec9636e5a06bbb8ee89dec95be2a10d35b1a32bb141a77b3b86ad670eeb18f945ccb515db7ca7ae240417ec7d2ba64
• Download URL:
  https://stacks.cdc.gov/view/cdc/184104/cdc_184104_DS1.pdf
• File Type:
  [PDF - 532.16 KB ]