Influence of dietary factors on the gastrointestinal absorption of lead.

Details

• Personal Author:
  Garber BT ; Wei E
• Description:
  Mice are given 0.2, 2 and 20 milligrams per kilogram orally of lead- acetate (301042) labeled with lead-210. The mean absorption of lead (7439921) is approximately 5 percent for all doses. The presence of food in the gastrointestinal tract reduced lead absorption when a tracer dose was administered but did not affect absorption after 2 milligrams per kilogram. The chelators nitrilotriacetic-acid and sodium-citrate increased absorption of lead, as did orange juice, a source of citric-acid (77929). Milk and the chelating agents, ethylenediaminetetraacetic-acid (60004) and diethylenetriaminepentaacetic-acid (67436) , did not significantly affect lead absorption. Dietary factors are considered useful in determining acceptable levels of lead in food. [Description provided by NIOSH]
• Subjects:
  Acetamides Chelating Agents Citrates Diet Digestive System Edetic Acid Food Contamination Hazardous Substances Lead Lead Poisoning Metals, Heavy Nervous System Occupational Health Safety

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• Keywords:
  Acetic-acids Chelates Dietary-effects EDTA Food-contamination Gastrointestinal-system Heavy-metals Lead-absorption Lead-poisoning Neurotoxic-effects NIOSH-Grant NIOSH-Publication Organo-lead-compounds Toxic-dose Toxic-substances Toxic-tolerance Toxicity

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• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  27
• Issue:
  3
• NIOSHTIC Number:
  nn:00050171
• Citation:
  Toxicol Appl Pharmacol 1974 Mar; 27(3):685-691
• Contact Point Address:
  Public Health University of California 108 Earl Warren Hall Berkeley, Calif 94720
• CAS Registry Number:
  Citric acid (CAS RN 77-92-9) ; Diethylenetriaminepentaacetic acid (CAS RN 67-43-6) ; Ethylenediaminetetraacetic acid (CAS RN 60-00-4) ; Lead (CAS RN 7439-92-1) ; Lead diacetate (CAS RN 301-04-2)
• Federal Fiscal Year:
  1974
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  University of California Berkeley, Berkeley, California
• Peer Reviewed:
  True
• Start Date:
  19710701
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  19820831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f6809664967999cd5bf528fffc4ae7f3b8fddba21a9dd07a81f33956820db7f974c9ab60473dd30310fd99316433f6689669ff2c191fe09e8fc4343343eddd54
• Download URL:
  https://stacks.cdc.gov/view/cdc/184059/cdc_184059_DS1.pdf
• File Type:
  [PDF - 835.97 KB ]